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Structural patterns in globular proteins

Abstract

A simple diagrammatic representation has been used to show the arrangement of α helices and β sheets in 31 globular proteins, which are classified into four clearly separated classes. The observed arrangements are significantly non-random in that pieces of secondary structure adjacent in sequence along the polypeptide chain are also often in contact in three dimensions.

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Levitt, M., Chothia, C. Structural patterns in globular proteins. Nature 261, 552–558 (1976). https://doi.org/10.1038/261552a0

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