Abstract
A cold-sensitive mutant of CHO cells has features of “reverse transformation” at the non-permissive temperature of 33 °C. Cells accumulate at G1 with altered morphology and remain viable and quiescent for more than 40 d. Such cultures are synchronised by a temperature shift back to the permissive 39 °C.
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Crane, M., Thomas, D. Cell-cycle, cell-shape mutant with features of the G0 state. Nature 261, 205–208 (1976). https://doi.org/10.1038/261205a0
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DOI: https://doi.org/10.1038/261205a0
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