Abstract
WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1–3 and the 1,2-diacylglycerol content of their membranes was increased2–4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.
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ALLAN, D., BILLAH, M., FINEAN, J. et al. Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]. Nature 261, 58–60 (1976). https://doi.org/10.1038/261058a0
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DOI: https://doi.org/10.1038/261058a0
