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Increasing effects of repetitive cocaine administration in the rat


REPORTS of chronic cocaine (and related psychomotor stimulant) administration suggest that tolerance develops to many drug effects1–3. A few studies of high dose cocaine administration have suggested that, on the contrary, repetitive administration may be associated with increasing effects on cocaine-induced convulsions in the rat4,5 and monkey6 and increasing bizarre visual and inhibitory behaviour, as well as dyskinesias, in the monkey6. We now report for the first time that repetitive cocaine administration can be associated with progressively increasing effects on horizontal and vertical hyperactivity as well as stereotypy in the rat.

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POST, R., ROSE, H. Increasing effects of repetitive cocaine administration in the rat. Nature 260, 731–732 (1976).

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