Abstract
OESTROGEN-SENSITIVE cells contain cytoplasmic macro-molecules called receptors1,2. They bind oestrogen to form complexes which are translocated to the nucleus where they may bind to specific acceptor sites3–5. This interaction of receptor–hormone complex with nuclear acceptor sites is assumed to be responsible for the stimulation of RNA, DNA and protein synthesis that results in growth of the tissue3–5. The demonstration of nuclear acceptor sites has been difficult and controversial6,7. We present here evidence that a limited number of receptor–oestrogen complexes are bound in the nucleus of rat uterine cells and that these sites may be specific nuclear acceptor sites.
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References
Gorski, J., Toft, D., Shyamala, G., Smith, D., and Notides, A., Rec. Prog. Hormone Res., 24, 45–80 (1968).
Jensen, E. V., and DeSombre, E. R., A. Rev. Biochem., 41, 203–230 (1972).
O'Malley, B. W., and Means, A. R., Science, 183, 610–620 (1974).
Anderson, J. N., Peck, E. J., Jr, and Clark, J. H., Endocrinology, 92, 1488–1495 (1973).
Clark, J. H., Anderson, J. N., and Peck, E. J., Jr, in Receptors for Reproductive Hormones, 36 (edit. by O'Malley, B. W., and Means, A. R.), 15–59 (Plenum, New York, 1973).
Chamness, G. C., Jennings, A. W., and McGuire, W. L., Biochemistry, 13, 327–331 (1974).
Buller, R. E., Schrader, W. T., and O'Malley, B. W., J. biol. Chem., 250, 809–818 (1975).
Alberga, A., Massol, N., Raynaud, J. P., and Baulieu, E. E., Biochemistry, 10, 3835 (1971).
Fang, S., and Liao, S., J. biol. Chem., 246, 16–24 (1971).
Mainwaring, W. I. P., and Peterken, B. M., Biochem. J., 125, 285–295 (1971).
King, R. J. B., and Gordon, J., Nature new Biol., 240, 185–187 (1972).
O'Malley, B. W., Spelsberg, T. C., Schrader, W. T., Chytil, F., and Steggles, A. W., Nature, 235, 141–144 (1972).
Higgins, S. J., Rousseau, G. G., Baxter, J. D., and Tomkins, G. M., J. biol. Chem., 248, 5873–5879 (1973).
Kalimi, M., Beato, M., and Feigelson, P., Biochemistry, 12, 3365–3371 (1973).
Chamness, G. C., Jennings, A. W., and McGuire, W. L., Nature, 241, 458–460 (1973).
Audre, J., and Rochefort, H., FEBS Lett., 50, 319–323 (1975).
Yamamoto, K. R., and Alberts, B., Cell, 4, 301–310 (1975).
Clark, J. H., and Gorski, J., Biochim. biophys. Acta, 192, 508–515 (1969).
Anderson, J. N., Clark, J. H., and Peck, E. J., Jr, Biochem. biophys. Res. Commun., 48, 1460–1468 (1972).
Anderson, J. N., Peck, E. J., Jr, and Clark, J. H., Endocrinology, 96, 160–167 (1975).
Clark, J. H., Peck, E. J., Jr, Schrader, W. T., and O'Malley, B. W., in Methods in Cancer Research (edit. by Busch and Harris (Academic, in the press).
Puca, G. A., and Brecni, F., Nature, 218, 967–969 (1968).
DeHertogh, R., Ekka, E., Vanderheyden, J., and Hoet, J. J., J. Steroid Biochem., 4, 313–320 1973).
Mester, J., and Baulieu, E. E., Biochem. J., 146, 617 (1975).
Anderson, J., Clark, J. H., and Peck, E. J., Jr, Biochem. J., 126, 561 (1972).
Sala-Trepat, J. M., and Reti, E., Biochim. biophys. Acta, 338, 92–103 (1974).
Jaffe, R. C., Socher, S. H., and O'Malley, B. W., Biochim. biophys. Acta, 399, 403–419 (1975).
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CLARK, J., PECK, E. Nuclear retention of receptor–oestrogen complex and nuclear acceptor sites. Nature 260, 635–637 (1976). https://doi.org/10.1038/260635a0
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DOI: https://doi.org/10.1038/260635a0
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