Abstract
EARLY work on the X-ray diffraction of DNA fibres showed that DNA can adopt different conformations, and up to now at least four different double-helical models have been described in detail: the A, B, C, and D forms1–4. During recent years, it has become likely that DNA in solution also occurs in different conformations5–7. For studying such helix–helix transitions synthetic polynucleotides with a defined sequence offer an important tool, since in natural DNA only a very small fraction of the molecule usually has a particular sequence and, sequence-specific effects of the conformation will therefore escape detection.
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References
Fuller, W., Wilkins, M. H. F., Wilson, H. R., Hamilton, L. D., and Arnott, S., J. molec. Biol., 12, 60–80 (1965).
Langridge, R., et al., J. molec. Biol., 2, 38–62 (1960).
Marvin, D. A., Spencer, M., Wilkins, M. H. F., and Hamilton, L. D., J. molec. Biol., 3, 547–565 (1961).
Arnott, S., Chandrasekaran, R., Hukins, D. W. L., Smith, P. J. C., and Watts, L., J. molec. Biol., 88, 523–533 (1974).
Pohl, F. M., and Jovin, T. M., J. molec. Biol., 67, 375–396 (1972).
Ivanov, V. I., Minchenkova, L. E., Minyat, E. E., Frank-Kamenetskii, M. D., and Schyolkina, A. K., J. molec. Biol., 87, 817–833 (1974).
Bram, S., Nature new Biol., 232, 174–176 (1971).
Arnott, S., Jerusalem Symp. Quantum Chem. Biochem., 5 (edit. by Bergmann, E. D., and Pullman, B.), 102–110 (1972).
Gratzer, W. B., Hill, L. R., and Owen, R. L., Eur. J. Biochem., 15, 209–214 (1970).
Gray, D. M., and Ratcliff, R. L., Biopolymers, 14, 487–498 (1975).
Pohl, F. M., Ranade, A., and Stockburger, M., Biochim. biophys. Acta, 335, 85–92 (1973).
Pilet, J., and Brahms, J., Nature new Biol., 236, 99–100 (1972).
Tunis-Schneider, M. J. B., and Maestre, M. F., J. molec. Biol., 52, 521–541 (1970).
Mitsui, Y., et al., Nature, 228, 1166–1169 (1970).
Crick, F. H. C., and Klug, A., Nature, 255, 530–533 (1975).
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POHL, F. Polymorphism of a synthetic DNA in solution. Nature 260, 365–366 (1976). https://doi.org/10.1038/260365a0
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DOI: https://doi.org/10.1038/260365a0
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