Abstract
THE lac operon has long been an important model system for developing an understanding of the control of gene expression. Since the early studies of Jacob and Monod1 on the lac operon, much work has been devoted towards determining the mode of interaction between repressor and operator. Although it has been shown clearly that repressor physically binds operator2,3, the details of this interaction remain unknown. We report here results of experiments designed to investigate further the structure of the operator and its interaction with the repressor.
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References
Jacob, F., and Monod, J., J. molec. Biol, 3, 318–356 (1961).
Gilbert, W., and Muller-Hill, B., Proc. natn. Acad. Sci. U.S.A., 58, 2415–2421 (1967).
Ptashne, M., Nature, 214, 232–234 (1967).
Gilbert, W., and Maxam, A., Proc. natn. Acad. Sci. U.S.A., 70, 3581–3584 (1973).
Bernardi, G., Adv. Enzymol., 31, 1–49 (1968).
Gierer, A., Nature, 212, 1480–1481 (1966).
Sobell, H., Proc. natn. Acad. Sci. U.S.A., 69, 2483–2487 (1972).
Dickson, R., Abelson, J., Barnes, W., and Reznikoff, W., Science, 187, 27–35 (1975).
Dykes, G., Bambara, R., Marians, K., and Wu, R., Nucl. Acids Res., 2, 327–345 (1975).
Allet, B., and Bukhari, A., J. molec. Biol., 92, 529–540 (1975).
Gilbert, W., Gralla, J., Majors, J., and Maxam, A., Protein–Ligand Interactions, 193–210 (Walter de Gruyter, Berlin, 1975).
Wang, J. C., Barkley, M. D., and Bourgeois, S., Nature, 251, 247–249 (1974).
Richmond, T. J., and Steitz, T. A., Fedn Proc., 34, Abs. 554 (1975).
Chan, H., and Wells, R., Nature, 252, 205–209 (1974).
Rushizky, G. W., Shaternikov, V. A., Mosejko, J. H., and Sober, H. A., Biochemistry, 14, 4221–4226 (1975).
Shenk, T., Rhodes, C., Rigby, P., and Berg, P., Proc. natn. Acad. Sci. U.S.A., 72, 989–993 (1975).
Vogt, V., Eur. J. Biochem., 33, 192–200 (1973).
Wu, R., Padmanabhan, R., and Bambara, R., Meth. Enzymol., 29 E, 231–253 (1974).
Kelly, T. J., and Smith, H. O., J. molec. Biol., 51, 393–409 (1970).
Platt, T., Files, J. G., and Weber, K., J. biol. Chem., 248, 110–121 (1973).
Donelson, J., and Wu, R., J. biol. Chem., 247, 4661–4668 (1972).
Ardelt, W., and Laskowski, M., Sr, Biochem. biophys. Res. Commun., 44, 1205–1211 (1971).
Wu, R., Jay, E., and Roychoudhury, R., in Methods in Cancer Research, 12, (Academic, New York, 1976).
Kössel, H., and Roychoudhury, R., Eur. J. Biochem., 22, 271–276 (1971).
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MARIANS, K., WU, R. Structure of the lactose operator. Nature 260, 360–363 (1976). https://doi.org/10.1038/260360a0
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DOI: https://doi.org/10.1038/260360a0
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