Abstract
THE isolation of a type C RNA tumour virus (HL23V) from cultured human acute myelogenous leukaemia peripheral blood leukocytes has recently been reported1,2. The reverse transcriptase of this putative human oncornavirus was found1 to be immunologically related to the reverse transcriptase of the simian sarcoma virus, type 1 (SSV-1), the gibbon ape lymphoma virus (GALV), and to a small extent in secondary culture, RD114 (ref. 2). The spontaneously released virus was shown to be infectious for several cell cultures, including a human rhabdomyosarcoma cell line, A204 (ref. 2). This culture produced virus in sufficient quantities to permit biochemical studies. Here we describe the characterisation of the virus(es) grown in this culture. We find that the particles produced by the A204 culture infected with HL23V are a mixture of two viruses that are indistinguishable immunologically and in nucleotide sequence from two known non-human primate viruses, the baboon endogenous virus (BV-M7)3,4 and the woolly monkey virus (SSV-1)5.
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CHAN, E., PETERS, W., SWEET, R. et al. Characterisation of a virus (HL23V) isolated from cultured acute myelogenous leukaemic cells. Nature 260, 266–268 (1976). https://doi.org/10.1038/260266a0
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DOI: https://doi.org/10.1038/260266a0
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