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Evidence for a new diffusible element of mating pheromones in yeast


THE yeast Saccharomyces cerevisiae produces pheromones which seem to participate in the mating process1,2. Each of the two haploid mating types (a or α) produces a diffusible factor (called a factor or α factor, respectively) which causes cells of the opposite mating type to be retarded in the G1 period of the cell division cycle3–6. The pheromones thus act to synchronise the cell cycles of mating cells before the formation of the diploid zygote. By a variation of the original assay for yeast mating pheromones8,9, we have observed that cells of mating type a produce a new pheromone which inhibits action of the α factor.

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HICKS, J., HERSKOWITZ, I. Evidence for a new diffusible element of mating pheromones in yeast. Nature 260, 246–248 (1976).

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