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Facilitation or attenuation of mixed leukocyte culture responsiveness by adherent cells

Nature volume 260, pages 145–146 (1976)Cite this article

Abstract

IT is generally agreed that adherent cells, or macrophages, are required for maximum reactivity in mixed leukocyte culture (MLC). The system has been incompletely defined, for the mode of function of the adherent cell is unclear. There is evidence from human and animal systems that adherent cells have either a nonspecific helper role1–4 or a more precise genetically defined stimulator role5. We report here that adherent cells which ingest latex particles seem to be capable of nonspecifically facilitating or attenuating human lymphocyte proliferation in MLC.

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References

  1. Gordon, J., Proc. Soc. exp. Biol. Med., 127, 30–33 (1968).

    Article  CAS  Google Scholar 

  2. Twomey, J. J., Sharkey, O., Jr, Brown, J. A., Laughter, A. H., and Jordan, P. H., J. Immun., 104, 845–853 (1970).

    CAS  Google Scholar 

  3. Levis, W. R., and Robbins, J. H., Transplantation, 9, 515–518 (1970).

    Article  Google Scholar 

  4. Rode, H. N., and Gordon, J., Cell. Immun., 13, 87–94 (1974).

    Article  CAS  Google Scholar 

  5. Greineder, D. K., Rosenthal, A. S., J. Immun., 114, 1541–1547 (1975).

    CAS  PubMed  Google Scholar 

  6. Ly, I. A., and Mishell, R. I., J. Immun. Meth., 5, 239–247 (1974).

    Article  CAS  Google Scholar 

  7. Jørgenson, F., and Lamm, L. U., Tissue Antigens, 4, 482–494 (1974).

    Article  Google Scholar 

  8. Thorsby, E., et al., Tissue Antigens, 4, 507–525 (1974).

    Article  Google Scholar 

  9. Rode, H. N., and Gordon, J., J. Immun., 104, 1453–1457 (1970).

    CAS  PubMed  Google Scholar 

  10. Alter, B. J., and Bach, F. H., Cell. Immun., 1, 207–218 (1970).

    Article  CAS  Google Scholar 

  11. Calderon, J., and Unanue, E. R., Nature, 253, 359–361 (1975).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021

    N. T. BERLINGER, C. LOPEZ & R. A. GOOD

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  1. N. T. BERLINGER
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  2. C. LOPEZ
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  3. R. A. GOOD
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BERLINGER, N., LOPEZ, C. & GOOD, R. Facilitation or attenuation of mixed leukocyte culture responsiveness by adherent cells. Nature 260, 145–146 (1976). https://doi.org/10.1038/260145a0

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