Abstract
CELLULAR content of ribosomes is coordinately regulated with cell growth1, either at the level of ribosome processing or ribosomal degradation. The two ribosomal subunits in growing mammalian cells are synthesised in equimolar amounts as cleavage products of a common precursor2; and it also seems that all the components of ribosomes are degraded as a unit3. The regulatory mechanism of ribosome metabolism in mammalian cells, however, remains unclear.
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KUMAR, A., BANDMAN, E. & MELVIN, W. Ribosome metabolism in temperature-sensitive mutant of BHK cells. Nature 259, 692–694 (1976). https://doi.org/10.1038/259692a0
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DOI: https://doi.org/10.1038/259692a0
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