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Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage


SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1–6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.

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NEWMAN, S., BIRNBAUM, J. & YEOH, G. Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage. Nature 259, 417–418 (1976).

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