Abstract
SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1–6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.
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References
Paul, J., and Gilmour, R. S., J. molec. Biol., 34, 305 (1968).
Stein, G. S., Spelsberg, T. C., and Kleinsmith, L. J., Science, 183, 817 (1974).
Barrett, T., Maryanka, D., Hamlyn, P. H., and Gould, H. J., Proc. natn. Acad. Sci. U.S.A., 71, 5057 (1974).
Johnson, J. D., Douvas, A. S., and Bonner, J., Int. Rev. Cytol., Suppl., 4, 273 (1974).
Elgin, S. C. R., and Bonner, J., Biochemistry, 9, 4440 (1970).
Teng, C. S., Teng, C. T., and Allfrey, V. G., J. biol. Chem., 246, 3597 (1971).
Loeb, J., and Creuzet, C., Bull. Soc. chim. Biol., 52, 1007 (1970).
Richter, K. H., and Sekeris, C. E., Archs Biochem. Biophys., 148, 44 (1972).
Elgin, S. C. R., and Hood, L. E., Biochemistry, 12, 4984 (1973).
Hill, R. J., Poccia, D. L., and Doty, P., J. molec. Biol., 61, 445 (1972).
Cognetti, G., Settineri, D., and Spinelli, G., Expl Cell Res., 71, 465 (1972).
Stein, G. S., and Borun, T. W., J. Cell Biol., 52, 292 (1972).
Stein, G. S., and Farber, J., Proc. natn. Acad. Sci. U.S.A., 69, 2918 (1972).
Platz, R., Stein, G. S., and Kleinsmith, L. J., Biochem. biophys. Res. Commun., 51, 735 (1973).
Newman, S. A., and Mayne, R., J. Cell Biol., 63, 244a (1974).
Saunders, J. W., Jr, J. exp. Zool., 108, 363 (1948).
Coon, H. G., Proc. natn. Acad. Sci. U.S.A., 55, 66 (1966).
Humason, G. L., Animal Tissue Techniques, 329 (Freeman, San Francisco and London, 1967).
Miller, E. J., and Matukas, V. J., Proc. natn. Acad. Sci. U.S.A., 64, 1264 (1969).
Dienstman, S. R., Biehl, J., Holtzer, S., and Holtzer, H., Devl Biol., 39, 83 (1974).
Chong, M. T., Garrard, W. T., and Bonner, J., Biochemistry, 13, 5128 (1974).
Ballal, N. R., Goldberg, D., and Busch, H., Biochem. biophys. Res. Commun., 62, 972 (1975).
Laemmli, U. K., Nature, 227, 680 (1970).
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NEWMAN, S., BIRNBAUM, J. & YEOH, G. Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage. Nature 259, 417–418 (1976). https://doi.org/10.1038/259417a0
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DOI: https://doi.org/10.1038/259417a0
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