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Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage

Nature volume 259, pages 417–418 (1976)Cite this article

Abstract

SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1–6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.

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Author notes

  1. STUART A. NEWMAN

    Present address: Department of Biological Sciences, State University of New York, Albany, New York, 12222

Authors and Affiliations

  1. Department of Anatomy, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, 19174

    STUART A. NEWMAN, JOHANNA BIRNBAUM & GEORGE C. T. YEOH

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NEWMAN, S., BIRNBAUM, J. & YEOH, G. Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage. Nature 259, 417–418 (1976). https://doi.org/10.1038/259417a0

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