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Thymine hydroperoxide as a mediator in ionising radiation mutagenesis

Nature volume 259, pages 341–342 (1976)Cite this article

Abstract

WE describe the mutagenic action of chemically synthesised cis-5,6-dihydro-6-hydroperoxy-5-hydroxythymine (6-TOOH)1 on transforming DNA of Haemophilus influenzae2,3, and suggest a mechanism by which ionising radiation induces mutations in vivo.

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Authors and Affiliations

  1. Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, 21205

    H. F. THOMAS, R. M. HERRIOTT, B. S. HAHN & S. Y. WANG

Authors
  1. H. F. THOMAS
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  2. R. M. HERRIOTT
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  3. B. S. HAHN
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  4. S. Y. WANG
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THOMAS, H., HERRIOTT, R., HAHN, B. et al. Thymine hydroperoxide as a mediator in ionising radiation mutagenesis. Nature 259, 341–342 (1976). https://doi.org/10.1038/259341a0

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