INFECTION of chick embryo fibroblasts with Rous sarcoma virus (RSV) induces a cell-specified plasminogen activator1. Induction occurs with transforming viruses but not with lytic viruses or with oncornaviruses which are not themselves transforming2. Similarly, many mammalian cell lines and embryo cultures transformed with either viruses or chemical carcinogens may be high producers of plasminogen activator in contrast to their untransformed counterparts3–6. A correlation has been demonstrated between production of plasminogen activator and various features of the transformed phenotype, such as cell locomotion, morphology and loss of anchorage-dependent growth4,7. Several established cell lines which are not highly tumorigenic or transformed by the usual criteria are, however, active producers of plasminogen activator; there are examples also of transformed or tumorigenic cell lines which do not produce significant levels of plasminogen activator3,8–10.
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Unkeless, J. C., Dano, K., Kellerman, G. M., and Reich, E., J. biol. Chem., 249, 4295–4305 (1974).
Unkeless, J.C., et al., J. exp. Med., 137, 85–111 (1973).
Weinstein, I. B., Wigler, M., and Stadler, U., WHO–IARC Workshop Rapid Screening Tests to Predict Late Toxic Effects of Environmental Chemicals, (International Agency for Research on Cancer, Lyon, in the press).
Pollack, R., Risser, R., Conlon, S., and Rifkin, D., Proc. natn. Acad. Sci. U.S.A., 71, 4792–4796 (1974).
Jones, P., Benedict, W., Strickland, S., and Reich, E., Cell, 5, 323–329 (1975).
Ossowski, L., Unkeless, J. C., Tobia, A., Quigley, J. P., and Reich, E., J. exp. Med., 137, 112–126 (1973).
Ossowski, L., Quigley, J. P., Kellerman, G. M., and Reich, E., J. exp. Med., 138, 1056–1064 (1973).
Mott, D. M., Fabisch, P. H., Sani, B. P., and Sorof, S., Biochem. biophys. Res. Commun., 61, 621–627 (1974).
Lang, W. E., Jones, P. A., and Benedict, W. F., J. natn. Cancer Inst., 54, 173–179 (1974).
Wigler, M. H., Ford, J. P., and Weinstein, I. B., in Proteases and Biological Control (edit. by Reich, E., Rifkin, D. B., and Shaw, E.), 849–856 (Cold Spring Harbor Laboratory, New York, 1975).
Hecker, E., Cancer Res., 28, 2338–2349 (1968).
Troll, W., Rossman, T., Katz, J., Levitz, M., and Sugimura, T., in Proteases and Biological Control (edit. by Reich, E. Rifkin, D. B., and Shaw, E.), 977–987 (Cold Spring Harbor Laboratory, New York, 1975).
Deutsch, D. G., and Mertz, E. T., Science, 170, 1095–1096 (1970).
Diamond, L., O'Brien, S., Donaldson, C., and Shimizu, Y., Int. J. Cancer, 13, 721–730 (1974).
Sivak, A., and Van Duuren, B. L., Science, 157, 1443–1444 (1967).
Suss, R., Kreibich, G., and Kinzel, V., Eur. J. Cancer, 8, 299–304 (1972).
Estensen, R. D., et al., in Control of Proliferation in Animal Cells (edit. by Clarkson, B., and Baserga, R.), 627–634 (Cold Spring Harbor Laboratory, New York, 1974).
Belman, S., and Troll, W., Cancer Res., 34, 3446–3455 (1974).
Mondal, S., Peterson, A. R., and Brankow, D. W., Proc. Am. Ass. Cancer Res., Abstr., 16, 74 (1975).
Eagle, H., Science, 122, 43–46 (1955).
Thompson, E. B., Tomkins, G. M., and Curran, J. F., Proc. natn. Acad. Sci. U.S.A., 56, 296–303 (1966).
Di Paolo, J. A., Donovan, P., and Nelson, R., J. natn. Cancer Inst., 42, 867–874 (1969).
Rubin, H., in Tissue Culture Methods and Applications (edit. by Kruse, P. F., and Patterson, M. K.), 119–122 (Academic, New York, 1973).
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WIGLER, M., WEINSTEIN, I. Tumour promotor induces plasminogen activator. Nature 259, 232–233 (1976). https://doi.org/10.1038/259232a0
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