New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid

Abstract

RECENT efforts to develop therapeutic agents for the treatment of sickle cell disease have led to the discovery of several antisickling agents1. We now report a new such agent, 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-butyric acid (DBA) (Compound 1). This compound efficiently prevents and reverses sickling, and has no acute toxicity in male mice.

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References

  1. 1

    Proc. first natn. Symp. Sickle Cell Disease, Washington DC Department of Health Education and Welfare Publication No. (NIH) 75–723 (1974).

  2. 2

    Eshiet, I. T., and Taylor, D. A. H., Chem. Commun., 467–468 (1966).

  3. 3

    Eshiet, I. T., and Taylor, D. A. H., J. chem. Soc. (C) 481–484 (1968).

  4. 4

    El-Said, F., Fadulu, S. O., Kuye, J. O., and Sofowara, E. A., Lloydia, 34, 172 (1971).

  5. 5

    Isaacs-Sodeye, W. A., et al., Acta haem., 53, 158–164 (1975).

  6. 6

    Edwards, M. J., and Martin, R. J., J. appl. Physiol., 21, 1898–1902 (1966).

  7. 7

    Severinghaus, J. W., J. appl. Physiol., 12, 485–486 (1958).

  8. 8

    Cerami, A., and Manning, J. M., Proc. natn. Acad. Sci. U.S.A., 68, 1180–1183 (1971).

  9. 9

    Roth, E. F., Nagel, R. L., Bookchin, R. M., and Grayzel, A. I., Biochem. biophys. Res. Commun., 48, 612–618 (1972).

  10. 10

    Lubin, B. H., et al., Proc. natn. Acad. Sci. U.S.A., 72, 43–46 (1975).

  11. 11

    Drabkin, D. L., J. biol. Chem., 164, 703–723 (1946).

  12. 12

    Bookchin, R. M., Nagel, R. L., and Ranney, H. M., J. biol. Chem., 242, 248–255 (1967).

  13. 13

    Clegg, J. B., Naughton, D. J., and Weatherall, D. J., J. molec. Biol., 19, 91–108 (1966).

  14. 14

    Metafora, S., Terada, M., Dow, L. W., Marks, P. A., and Bank, A., Proc. natn. Acad. Sci. U.S.A., 69, 1299–1303 (1972).

  15. 15

    May, A., Bellingham, A. J., Huehns, E. R., Beavan, G. H., Lancet, i, 658–661 (1972).

  16. 16

    Lee, C. K., Manning, J. M., J. biol. chem., 248, 5861–5865 (1973).

  17. 17

    Tosteson, D. C., Carlsen, E., Dunham, E. T., J. gen. physiol., 39, 31–53 (1956).

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EKONG, D., OKOGUN, J., ENYENIHI, V. et al. New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid. Nature 258, 743–746 (1975). https://doi.org/10.1038/258743a0

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