New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid


RECENT efforts to develop therapeutic agents for the treatment of sickle cell disease have led to the discovery of several antisickling agents1. We now report a new such agent, 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-butyric acid (DBA) (Compound 1). This compound efficiently prevents and reverses sickling, and has no acute toxicity in male mice.

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EKONG, D., OKOGUN, J., ENYENIHI, V. et al. New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid. Nature 258, 743–746 (1975).

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