Abstract
IN androgen-resistant male mice of genotype Tfm/Y spermatogenesis is arrested at first meiotic division. This is likely to be due, at least in part, to the need for testosterone if spermatogenesis is to proceed beyond prophase of first meiosis1. It would be somewhat surprising if the response to androgen involved any gene action in the developing sperm cell itself, since the locus of the gene for response to androgen, Tfm, is on the X chromosome2. The X–Y chromosome pair is believed to become genetically inactive during meiotic prophase3, and at stages beyond meiosis I only 50% of spermatocytes and spermatids possess an X chromosome.
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LYON, M., GLENISTER, P. & LYNN LAMOREUX, M. Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis. Nature 258, 620–622 (1975). https://doi.org/10.1038/258620a0
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DOI: https://doi.org/10.1038/258620a0
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