Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Human serum lyses RNA tumour viruses

Abstract

ALTHOUGH there is agreement that oncornaviruses infect and are associated with malignancies in mice, cats and chickens1, the evidence for oncornavirus infection in man remains controversial2. Similarly, antibodies to oncornavirus antigens have been detected in laboratory animals3–7, but there are few data indicating the presence of such antibodies in humans3,8,9. These findings suggest that man possesses a natural defence mechanism which inhibits or interferes with oncornavirus infection and replication. We report here evidence for such a mechanism.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. The Molecular Biology of Tumour Viruses (edit. by Tooze, J.), (Cold Spring Harbor Laboratory, New York, 1973).

  2. Nature, 254, 101–102 (1975).

    Article  ADS  Google Scholar 

  3. Sarma, P. S., Sharar, A., Walters, V., and Gardner, M., Proc. Soc. exp. Biol. Med., 145, 560–564 (1974).

    Article  CAS  Google Scholar 

  4. Jarrett, W., Essex, M., Mackey, L., Jarrett, O., and Laird, H., J. natn. Cancer Inst., 51, 261–263 (1973).

    Article  CAS  Google Scholar 

  5. Ihle, J. N., Hanna, M. G., Robertson, L. E., and Kenney, I. T., J. exp. Med., 139, 1568–1581 (1974).

    Article  CAS  Google Scholar 

  6. Essex, M., Adv. Cancer Res., 21, 175–248 (1975).

    Article  CAS  Google Scholar 

  7. Andrewes, C. H., J. Path. Bact., 48, 225–227 (1939).

    Article  Google Scholar 

  8. Charman, H. P., Kim, N., White, M., and Gilden, R. V., J. natn. Cancer Inst., 52, 1409–1413 (1974).

    Article  CAS  Google Scholar 

  9. Hersh, E. M., et al., J. natn. Cancer Inst., 53, 327–333 (1974).

    Article  CAS  Google Scholar 

  10. Klement, V., Rowe, W. P., Hartley, J. W., and Pugh, W. E., Proc. natn. Acad. Sci. U.S.A., 63, 753–758 (1969).

    Article  ADS  CAS  Google Scholar 

  11. Oroszlan, S., and Gilden, R. V., Science, 168, 1478–1480 (1970).

    Article  ADS  CAS  Google Scholar 

  12. Blatti, S. P., et al., Cold Spring Harb. Symp. quant. Biol., 35, 649–657 (1970).

    Article  CAS  Google Scholar 

  13. Manni, J. A., and Müller-Eberhard, H. J., J. exp. Med., 130, 1145–1160 (1969).

    Article  CAS  Google Scholar 

  14. Stolfi, R. L., J. Immun., 100, 46–54 (1968).

    CAS  PubMed  Google Scholar 

  15. Pinckard, R. N., et al., J. Immun., 110, 1376–1382 (1973).

    CAS  PubMed  Google Scholar 

  16. Kaplan, M. H., and Volanakis, J. E., J. Immun., 112, 2135–2147 (1974).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WELSH, R., COOPER, N., JENSEN, F. et al. Human serum lyses RNA tumour viruses. Nature 257, 612–614 (1975). https://doi.org/10.1038/257612a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/257612a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing