STUDIES on the pharmacology of the noradrenergic cyclic AMP-generating system in slices from the limbic forebrain of the rat1 and on adaptive properties of this system in conditions of persistent changes in the availability of nor-adrenaline (NA) have revealed that the system may serve as a model for the central NA receptor in this area, and that its sensitivity to NA increases or decreases when the availability of NA at the receptor site decreases or increases respectively2,3. Thus, hypersensitivity of the system has been achieved by treatment with reserpine2, a drug known to precipitate occasionally severe depressive reactions in man4, and the syndrome of which, when elicited in animals, is widely used as a model for depression5–7. Conversely, the monoamine oxidase (MAO) inhibitors, pargyline and nialamide, caused a marked reduction in the reactivity of the cyclic AMP-generating system to NA after chronic administration3. To determine whether or not antidepressant drugs which do not elevate the level of monoamines in brain share the effect of MAO inhibitors on the noradrenergic cyclic AMP-generating system, we studied the effect of the tricyclic antidepressants, desipramine and iprindole, on the reactivity of the system to NA. Desipramine blocks the uptake of NA through the neuronal membrane8,9 whereas iprindole neither blocks the neuronal uptake of NA nor alters its metabolism or turnover10,11, but is nevertheless a potent antidepressant12–14. In addition, we have tested the effect of electroconvulsive treatment (ECT), as it is generally accepted to be one of the most effective treatments for severe depression15.
Subscribe to Journal
Get full journal access for 1 year
only $3.83 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Blumberg, J. B., Taylor, R. E., and Sulser, F., J. Pharm. Pharmac., 27, 125–128 (1975).
Blumberg, J. B., Vetulani, J., Stawarz, R. J., and Sulser, F., J. Pharmac. exp. Ther. (in the press).
Vetulani, J., Stawarz, R. J., Blumberg, J. B., and Sulser, F., Fedn Proc. 34, 269 (1975).
Bunney, W. E., and Davis, J. M., Archs gen. Psychiat., 13, 483–494 (1975).
Sulser, F., Watts, J. S., and Brodie, B. B., Ann. N.Y. Acad. Sci., 96, 279–288 (1962).
Vernier, V. G., Hanson, H. M., and Stone, C. A., in Psychosomatic Medicine (edit. by Nodine, T. H., and Moyer, J. H.), 683–690 (Lea and Febiger, Philadelphia, 1962).
Sulser, F., and Dingell, J. V., in Antidepressant Drugs of Non-MAO Inhibitor Type (edit. by Efron, D. H., and Kety, S. S.), 1–19 (US Department of Health, Education and Welfare, Washington, DC, 1966).
Carlsson, A., and Waldeck, B., Acta Pharmac. Toxic., 22, 293–300 (1965).
Sulser, F., Owens, M. L., Strada, S. J., and Dingell, J. V., J. Pharmac. exp. Ther., 168, 272–282 (1969).
Freeman, J. J., and Sulser, F., J. Pharmac. exp. Ther., 183, 307–315 (1972).
Rosloff, B., and Davis, J. M., Psychopharmacologia, 40, 53–64 (1974).
Ayd, F. J., Dis. Nerv. Syst., 30, 818–824 (1969).
Hicks, J. T., Ill. Med. J., 128, 622–626 (1965).
McClatchey, W. T., Moffat, T., and Irvine, G. M., J. ther. clin. Res., 1, 13–19 (1967).
Denber, H. C. B., in Psychopharmacological Treatment (edit. by Denber, H. C. B.) 121–134 (Dekker, New York, 1975).
Kakiuchi, S., and Rall, T. W., Molec. Pharmac., 4, 367–378 (1968).
Palmer, G. C., Robison, G. A., Manian, A. A., and Sulser, F., Psychopharmacologia, 23, 201–211 (1972).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem. 193, 265–275 (1951).
Gilman, A. G., Proc. natn. Acad. Sci. U.S.A., 67, 305–312 (1970).
Matussek, N., and Ladisich, W., Psychopharmacologia, 15, 305–309 (1969).
Papeschi, R., Randrup, A., and Lal, S., Psychopharmacologia, 35, 149–158 (1974).
About this article
Cite this article
VETULANI, J., SULSER, F. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature 257, 495–496 (1975). https://doi.org/10.1038/257495a0
Analysis of Density Changes of Selected Brain Receptors After a 14-Day Supply of Chromium(III) and Evaluation of Chromium(III) Affinity to Selected Receptors and Transporters
Biological Trace Element Research (2019)
Brain and Neuroscience Advances (2019)
The Lancet Psychiatry (2017)
Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G Protein, Gαs
Journal of Biological Chemistry (2016)
International Journal of Molecular Sciences (2016)