Letter | Published:

Mitochondrial suppressor of a nuclear gene in Paramecium

Naturevolume 257pages312314 (1975) | Download Citation



THE biogenesis of mitochondria depends on two sources of genetic information: one in the nucleus and the other within the mitochondria. An important question raised by this situation is how information from the two sources becomes integrated to form a functional organelle4,11. Products coded by both mitochondrial and nuclear DNA have been shown to be assembled in the mitochondrial inner membrane to form complex enzymes such as ATPase, cytochrome oxidase, cytochrome b and mutations in either genome can affect enzyme activity2,6,7,14. Since the activity of such enzymes depends on molecular interactions between their component subunits, it is conceivable that a defect in one subunit can be, at least partly, corrected by a mutation affecting another subunit. A nuclear mutation suppressing the effect of a mutated mitochondrial gene has been studied in Neurospora8. We report here the reverse situation.

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  1. Centre de Génétique Moléculaire du CNRS, 91190, Gif-sur-Yvette, France



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