Letter | Published:

Regulation of chromosome 21-directed anti-viral gene(s) as a consequence of age

Nature volume 257, pages 310312 (25 September 1975) | Download Citation

Subjects

Abstract

WHEN human fibroblast cells are cultured in vitro they undergo about 50 cell population doublings at which time their growth rate begins to slow down and they finally die1,2. For this reason, several investigators have used the senescence of human fibroblasts in vitro as a model system for experimental ageing research3–6. One explanation for human fibroblast senescence is that some cell functions are lost before cells reach their maximum division limit. We have described the existence of a complex regulatory gene function controlling the inducibility of chromosome 21-directed anti-viral gene(s) (AVG) in human fibroblasts7. Our conclusions were derived from experiments on human fibroblasts monosomic, disomic or trisomic for chromosome 21. We therefore used all three cell types in this study to test the preservation of this complex regulatory gene function in fibroblasts allowed to age in vitro and in fibroblasts derived from human donors of different ages. We found (1) that no differences exist in AVG expression in human fibroblasts allowed to age in vitro and (2) that the AVG in human fibroblasts derived from older human donors (64 yr) is easier to induce than it is in younger donors (0–29 yr).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Expl Cell. Res., 25, 585–621 (1961).

  2. 2.

    , Expl Cell Res., 37, 614–636 (1965).

  3. 3.

    , Adv. Gerontol. Res., 4, 45–78 (1972).

  4. 4.

    , , and , Lab. Invest., 23, 86–92 (1970)

  5. 5.

    , , and , Nature, 245, 316–319 (1973).

  6. 6.

    , , and , J. gen. Physiol., 83, 211–218 (1974).

  7. 7.

    , Nature, 253, 280–282 (1975).

  8. 8.

    , and , Science, 171, 77–79 (1971).

  9. 9.

    , and , Lancet, ii, 946 (1960).

  10. 10.

    , , , , and , Ann. Med. exp. Biol. Fenn., 43, 125 (1965).

Download references

Author information

Affiliations

  1. Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21205, and GRC Baltimore City Hospitals, Baltimore, Maryland 21224

    • Y. H. TAN
    • , E. L. CHOU
    •  & N. LUNDH

Authors

  1. Search for Y. H. TAN in:

  2. Search for E. L. CHOU in:

  3. Search for N. LUNDH in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/257310a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.