Letter | Published:

Localisation of human peptidase-A structural locus from studies on a cultured lymphoblastoid line

Nature volume 257, pages 308310 (25 September 1975) | Download Citation

Subjects

Abstract

LONG term genetic analysis of lymphoblastoid cell lines provides a practical means of studying the types of spontaneous and induced mutation that can occur in human somatic cells1,2 and of following the evolution of distinct populations of cells within a bulk culture3,4. Occasionally, data may be expected to emerge which facilitate the localisation of human structural genes. We now report the first such application of this technique.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , et al., Ann. Hum. Genet., 36, 247–266 (1973).

  2. 2.

    , , and , Proc. natn. Acad. Sci. U.S.A., 70, 1397–1400 (1973).

  3. 3.

    , , and , J. natn. Cancer Inst., 47, 1203–1214 (1971).

  4. 4.

    , et al., Ann. Hum. Genet., 39, 33–42 (1975).

  5. 5.

    , , , and , J. natn. Cancer Inst., 39, 745–754 (1967).

  6. 6.

    , , and , Chromosoma, 35, 310–325 (1971).

  7. 7.

    , Nature, 233, 555–556 (1971).

  8. 8.

    , J. med. Genet., 10, 122–126 (1973).

  9. 9.

    , et al., Cytogenet. Cell Genet., 12, 187–198 (1973).

  10. 10.

    , , , and , Birth Defects: Original Article Series X3, 128–129 (The National Foundation, New York, 1974).

  11. 11.

    , , , , and , Birth Defects: Original Article Series X3, 126–127 (The National Foundation, New York, 1974).

  12. 12.

    , et al., J. med. Genet., 11, 353–363 (1974).

  13. 13.

    , Cold Spring Harb. Symp. quant. Biol., 12, 179–191 (1947).

  14. 14.

    , Adv. Genet., 14, 133–169 (1968).

  15. 15.

    , and , Genetics, 57, 331–346 (1967).

  16. 16.

    , J. Genet., 48, 31–42 (1947).

  17. 17.

    , , and , Ann. Hum. Genet., 38, 309–320 (1975).

  18. 18.

    , Expl Cell Res., 75, 304–306 (1972).

Download references

Author information

Affiliations

  1. Medical Research Council, Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh, UK

    • ELIZABETH ARTHUR
    • , C. M. STEEL
    •  & H. J. EVANS
  2. Medical Research Council, Human Biochemical Genetics Unit, Galton Laboratory, University College London, UK

    • SUSAN POVEY
    • , B. WATSON
    •  & HARRY HARRIS

Authors

  1. Search for ELIZABETH ARTHUR in:

  2. Search for C. M. STEEL in:

  3. Search for H. J. EVANS in:

  4. Search for SUSAN POVEY in:

  5. Search for B. WATSON in:

  6. Search for HARRY HARRIS in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/257308a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.