Letter | Published:

Kinetics of inactivation of histone mRNA in the cytoplasm after inhibition of DNA replication in synchronised HeLa cells

Nature volume 257, pages 247248 (18 September 1975) | Download Citation

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Abstract

IN many eukaryotic cells DNA replication and histone synthesis proceed synchronously1–6. Interruption of DNA synthesis in synchronised HeLa cells results in an immediate decrease of histone synthesis as measured by incorporation of labelled amino acids into histones2,3 or by following the completion of nascent histone poly pep tide chains on polyribosomes in vitro 5.

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Affiliations

  1. Physiologisch-Chemisches Institut der Universität Marburg, Lahnberge, 355 Marburg/Lahn, West Germany

    • DIETER GALLWITZ

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DOI

https://doi.org/10.1038/257247a0

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