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Expression of H–Y (male) antigen in phenotypically female Tfm/Y mice

Nature volume 257, pages 236238 (18 September 1975) | Download Citation

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Abstract

THE X-linked testicular feminisation mutant (Tfm) in the mouse produces chromosomally male animals, XTfm/Y, with small testes but no other internal reproductive organs, and with female external genitalia1. This condition results fromfailure of target tissues to respond to testosterone, so that all characters of maleness that are testosterone-dependent are absent in males2–4.

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Affiliations

  1. Department of Anatomy, Cornell University Medical College, and Division of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 and MRC Radiobiology Unit, Harwell, Didcot, Berkshire, UK

    • DOROTHEA BENNETT
    • , EDWARD A. BOYSE
    • , MARY F. LYON
    • , BONNIE J. MATHIESON
    • , MARGRIT SCHEID
    •  & KAICHIRO YANAGISAWA

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https://doi.org/10.1038/257236a0

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