Letter | Published:

Isolation and properties of a murine spleen cell Fc receptor

Nature volume 257, pages 231233 (18 September 1975) | Download Citation

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Abstract

MURINE and human bone marrow-derived (B) lymphocytes have a cell surface-bound receptor for antibody complexed to antigen. Heat-aggregated immunoglobulin complexes will also bind to this receptor, and the binding is specifically mediated by means of the Fc portion of the IgG molecule1–3. So far, the only function ascribed to the Fc receptor is in the antibody-dependent lymphocyte-mediated cytotoxicity reaction3. A recent report has indicated, however, that the Fc receptor is identical to or closely associated with the Ia antigens on the B-cell membrane4. The Ia antigens are alloantigens coded for by the immune response region of the major histocompatibility complex5 and if indeed these antigens and the Fc receptor are identical, this would reveal a role for the receptor in several aspects of the immune response6.

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Affiliations

  1. Institute of Medical and Physiological Chemistry, Biomedical Center, University of Uppsala, Sweden

    • LARS RASK
    • , LARS KLARESKOG
    • , LARS ÖSTBERG
    •  & PER A. PETERSON

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https://doi.org/10.1038/257231a0

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