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Partial characterisation of Ia antigens on murine thymocytes

Naturevolume 257pages230231 (1975) | Download Citation



GENES controlling specific immune responsiveness at the level of activation of the thymus derived (T) lymphocyte, and collaboration of these cells with lymphocytes derived from the bursal equivalent (B lymphocytes), have been shown to be linked to the major histocompatibility complex (MHC) in many species1. The mechanism of action of these genes is not understood, and it has been postulated that they represent structural genes for a non-immunoglobulin receptor for antigen on T lymphocytes2.

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  1. 1

    Benacerraf, B., and Katz, D. H., Adv. Cancer Res., (in the press).

  2. 2

    Benacerraf, B., and McDevitt, H. O., Science, 175, 273–279 (1972).

  3. 3

    Shreffler, D. C., and David, C. S., Adv. Immun., 20, 125–195 (1975).

  4. 4

    Hammerling, G. J., Deak, B. D., Mauve, G., Hammerling, U., and McDevitt, H. O., Immunogenetics, 1, 68–81 (1974).

  5. 5

    Sachs, D. H., and Cone, J. L., J. exp. Med., 138, 1289–1304.

  6. 6

    David, C. S., Shreffler, D. C., and Frelinger, J. A., Proc. natn. Acad. Sci. U.S.A., 70, 2509–2514 (1973).

  7. 7

    Hammerling, G. J., Mauve, G., Goldberg, E., and McDevitt, H. O., Immunogenetics, 1, 428–437 (1975).

  8. 8

    Goding, J. W., Nossal, G. J. V., Shreffler, D. C., and Marchalonis, J. J., J. Immunogenet., 2, 41–57 (1975).

  9. 9

    Goding, J. W., and Warner, N. L., J. exp. Med., 142, 536–541 (1975).

  10. 10

    Frelinger, J. A., Niederhuber, J. E., David, C. S., and Shreffler, D. C., J. exp. Med., 140, 1273–1284 (1974).

  11. 11

    Marchalonis, J. J., Science (in the press).

  12. 12

    Munro, A. J., and Taussig, M. J., Nature, 256, 103–106 (1975).

  13. 13

    Cullen, S. E., David, C. S., Shreffler, D. C., and Nathenson, S. G., Proc. natn. Acad. Sci. U.S.A., 71, 648–652 (1974).

  14. 14

    Vitetta, E. S., Klein, J., and Uhr, J. W., Immunogenetics, 1, 82–90 (1974).

  15. 15

    Marchalonis, J. J., Cone, R. E., and Santer, V., Biochem. J., 124, 921–927 (1971).

  16. 16

    Laemmli, U. K., and Favre, M., J. molec. Biol., 80, 575–599 (1973).

  17. 17

    Cone, R. E., and Marchalonis, J. J., Biochem. J., 140, 345–354 (1974).

  18. 18

    Stevens, R. H., in Progress in Immunology II, 2 (edit. by Brent, L., and Holborow, J.), 137–145 (North Holland, Amsterdam, 1974).

  19. 19

    Haustein, D., and Goding, J. W., Biochem. Biophys. Res. Commun., 65, 483–490 (1975).

  20. 20

    Atwell, J. L., and Marchalonis, J. J., J. Immunogenet., 1, 367–391 (1975).

  21. 21

    von Boehmer, H., and Shortman, K., J. Immun. Meth., 2, 293–301 (1973).

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  1. Molecular Immunology Laboratory, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Parkville, 3050, Victoria, Australia



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