Letter | Published:

Partial characterisation of Ia antigens on murine thymocytes

Nature 257, 230–231 (1975) | Download Citation

Subjects

Abstract

GENES controlling specific immune responsiveness at the level of activation of the thymus derived (T) lymphocyte, and collaboration of these cells with lymphocytes derived from the bursal equivalent (B lymphocytes), have been shown to be linked to the major histocompatibility complex (MHC) in many species1. The mechanism of action of these genes is not understood, and it has been postulated that they represent structural genes for a non-immunoglobulin receptor for antigen on T lymphocytes2.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

References

  1. 1

    Benacerraf, B., and Katz, D. H., Adv. Cancer Res., (in the press).

    • 2

      Benacerraf, B., and McDevitt, H. O., Science, 175, 273–279 (1972).

    • 3

      Shreffler, D. C., and David, C. S., Adv. Immun., 20, 125–195 (1975).

    • 4

      Hammerling, G. J., Deak, B. D., Mauve, G., Hammerling, U., and McDevitt, H. O., Immunogenetics, 1, 68–81 (1974).

    • 5

      Sachs, D. H., and Cone, J. L., J. exp. Med., 138, 1289–1304.

      • 6

        David, C. S., Shreffler, D. C., and Frelinger, J. A., Proc. natn. Acad. Sci. U.S.A., 70, 2509–2514 (1973).

      • 7

        Hammerling, G. J., Mauve, G., Goldberg, E., and McDevitt, H. O., Immunogenetics, 1, 428–437 (1975).

      • 8

        Goding, J. W., Nossal, G. J. V., Shreffler, D. C., and Marchalonis, J. J., J. Immunogenet., 2, 41–57 (1975).

      • 9

        Goding, J. W., and Warner, N. L., J. exp. Med., 142, 536–541 (1975).

      • 10

        Frelinger, J. A., Niederhuber, J. E., David, C. S., and Shreffler, D. C., J. exp. Med., 140, 1273–1284 (1974).

      • 11

        Marchalonis, J. J., Science (in the press).

        • 12

          Munro, A. J., and Taussig, M. J., Nature, 256, 103–106 (1975).

        • 13

          Cullen, S. E., David, C. S., Shreffler, D. C., and Nathenson, S. G., Proc. natn. Acad. Sci. U.S.A., 71, 648–652 (1974).

        • 14

          Vitetta, E. S., Klein, J., and Uhr, J. W., Immunogenetics, 1, 82–90 (1974).

        • 15

          Marchalonis, J. J., Cone, R. E., and Santer, V., Biochem. J., 124, 921–927 (1971).

        • 16

          Laemmli, U. K., and Favre, M., J. molec. Biol., 80, 575–599 (1973).

        • 17

          Cone, R. E., and Marchalonis, J. J., Biochem. J., 140, 345–354 (1974).

        • 18

          Stevens, R. H., in Progress in Immunology II, 2 (edit. by Brent, L., and Holborow, J.), 137–145 (North Holland, Amsterdam, 1974).

          • 19

            Haustein, D., and Goding, J. W., Biochem. Biophys. Res. Commun., 65, 483–490 (1975).

          • 20

            Atwell, J. L., and Marchalonis, J. J., J. Immunogenet., 1, 367–391 (1975).

          • 21

            von Boehmer, H., and Shortman, K., J. Immun. Meth., 2, 293–301 (1973).

          Download references

          Author information

          Affiliations

          1. Molecular Immunology Laboratory, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Parkville, 3050, Victoria, Australia

            • JAMES W. GODING
            • , ELIZABETH WHITE
            •  & JOHN J. MARCHALONIS

          Authors

          1. Search for JAMES W. GODING in:

          2. Search for ELIZABETH WHITE in:

          3. Search for JOHN J. MARCHALONIS in:

          To obtain permission to re-use content from this article visit RightsLink.

          About this article

          Publication history

          Received

          Accepted

          Issue Date

          DOI

          https://doi.org/10.1038/257230a0

          Further reading

          Comments

          By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.