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Opiate receptor in normal and drug altered brain function*

Abstract

Recent biochemical identification of the receptor site for pharmacological actions of opiates helps elucidate how these drugs relieve pain, elicit euphoria and ‘addiction’, and provides simple, direct approaches to developing potentially non-addicting analgesics. The isolation of a morphine-like peptide which may be a central nervous system neurotransmitter sheds light on normal brain mechanisms regulating pain and emotion.

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References

  1. Goldstein, A., Lowney, L. L., and Pal, B. K., Proc. natn. Acad. Sci. U.S.A., 68, 1742–1747 (1971).

    Article  ADS  CAS  Google Scholar 

  2. Pert, C. B., and Snyder, S. H., Science, 179, 1011–1014 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Pert, C. B., and Snyder, S. H., Proc. natn. Acad. Sci. U.S.A., 70, 2243–2247 (1973).

    Article  ADS  CAS  Google Scholar 

  4. Terenius, L., Acta Pharmacol. Toxicol., 32, 317–320 (1973).

    Article  CAS  Google Scholar 

  5. Simon, E. J., Hiller, J. M., and Edelman, I., Proc. natn. Acad. Sci. U.S.A., 70, 1947–1949 (1973).

    Article  ADS  CAS  Google Scholar 

  6. Snyder, S. H., Pasternak, G. W., and Pert, C. B., in Handbook of Psychopharmacology (edit. by Iversen, L. L., Iversen, S. D., and Snyder, S. H.), 329–360. (Plenum, New York, 1975).

    Google Scholar 

  7. Loh, H. H., Cho, T. M., Wu, Y.-C., and Way, E. L., Life Sci., 14, 2231–2245 (1974).

    Article  CAS  Google Scholar 

  8. Abood, L. G.,, Hoss, W. P., Psychopharmacol. Commun., 1, 29–36 (1975).

    CAS  PubMed  Google Scholar 

  9. Paton, W. D. M., Br. J. Pharmac. Chemother., 12, 119–127 (1957).

    Article  CAS  Google Scholar 

  10. Kosterlitz, H. W., and Waterfield, A. A., A. Rev. Pharmac., 15, 29–47 (1975).

    Article  CAS  Google Scholar 

  11. Creese, I., and Snyder, S. H., J. Pharmac. exp. Ther., 194, 205–219 (1975).

    CAS  Google Scholar 

  12. Lasagna, L., Pharmac. Rev., 16, 47–83 (1964).

    CAS  Google Scholar 

  13. Pert, C. B., Pasternak, G. W., and Snyder, S. H., Science, 182, 1359–1361 (1973).

    Article  ADS  CAS  Google Scholar 

  14. Pert, C. B., and Snyder, S. H., Molec. Pharmac., 10, 868–879 (1974).

    CAS  Google Scholar 

  15. Simon, E. J., Hiller, J. M., Groth, J., and Edelman, I., J. Pharmac. exp. Ther., 192, 531–537 (1975).

    CAS  Google Scholar 

  16. Pasternak, G. W., and Snyder, S. H., Nature, 253, 563–565 (1975).

    Article  ADS  CAS  Google Scholar 

  17. Snyder, S. H., Neurosci. Res. Prog. Bull., 13, 137–141 (1975).

    CAS  Google Scholar 

  18. Pasternak, G. W., and Snyder, S. H., Molec. Pharmac., 10, 183–193 (1974).

    CAS  Google Scholar 

  19. Pasternak, G. W., and Snyder, S. H., Molec. Pharmac., 11, 478–484 (1975).

    CAS  Google Scholar 

  20. Pasternak, G. W., Wilson, H. A., and Snyder, S. H., Molec. Pharmac., 11, 340–351 (1975).

    CAS  Google Scholar 

  21. Wilson, H. A., Pasternak, G. W., and Snyder, S. H., Nature, 253, 448–450 (1975).

    Article  ADS  CAS  Google Scholar 

  22. Pasternak, G. W., Snowman, A., and Snyder, S. H., Molec. Pharmac. (in the press).

  23. Karlin, A., J. theor. Biol., 16, 306–320 (1967).

    Article  CAS  Google Scholar 

  24. Changeux, J. -P., and Podleski, T. R., Proc. natn. Acad. Sci. U.S.A., 59, 944–950 (1968).

    Article  ADS  CAS  Google Scholar 

  25. Snyder, S. H., Biochem. Pharmac., 24, 1371–1374 (1975).

    Article  CAS  Google Scholar 

  26. Young, A. B., and Snyder, S. H., Proc. natn. Acad. Sci. U.S.A., 70, 2832–2836 (1973).

    Article  ADS  CAS  Google Scholar 

  27. Young, A. B., and Snyder, S. H., Proc. natn. Acad. Sci. U.S.A., 71, 4002–4005 (1974).

    Article  ADS  CAS  Google Scholar 

  28. Nauta, W. J. H., Neurosci. Res. Prog. Bull., 13, 84–87 (1975).

    Google Scholar 

  29. Kuhar, M. J., Pert, C. B., and Snyder, S. H., Nature, 245, 447–450 (1973).

    Article  ADS  CAS  Google Scholar 

  30. Hiller, J. M., Pearson, J., and Simon, E. J., Res. Commun. chem. pathol. Pharmac., 6, 1052–1062 (1973).

    CAS  Google Scholar 

  31. Pert, A., and Yaksh, T., Brain Res., 80, 135–140 (1974).

    Article  CAS  Google Scholar 

  32. Wei, E. L., Loh, H. H., and Way, E. L., J. pharmac. exp. Ther., 185, 108–115 (1973).

    CAS  Google Scholar 

  33. Pert, C. B., Kuhar, M. J., and Snyder, S. H., Life Sci., 16, 1849–1854 (1975).

    Article  CAS  Google Scholar 

  34. Pert, C. B., and Snyder, S. H., Life Sci., 16, 1623–1634 (1975).

    Article  CAS  Google Scholar 

  35. Korf, J., Bunney, B. S., and Aghajanian, G. K., Eur. J. Pharmac., 25, 165–169 (1974).

    Article  CAS  Google Scholar 

  36. way, E. L., Neurosci. Res. Prog. Bull., 13, 112–118 (1975).

    CAS  Google Scholar 

  37. Pert, C. B., Aposhian, D., and Snyder, S. H., Brain Res., 75, 356–361 (1974).

    Article  CAS  Google Scholar 

  38. Pert, C. B., Snowman, A. M., and Snyder, S. H., Brain Res., 70, 184–188 (1974).

    Article  CAS  Google Scholar 

  39. Hughes, J., Brain Res., 88, 1–14 (1975).

    Article  ADS  Google Scholar 

  40. Terenius, L., and Wahlström, A., Life Sci., 16, 1759–1764 (1975).

    Article  CAS  Google Scholar 

  41. Pasternak, G. W., Goodman, R., and Snyder, S. H., Life Sci., 16, 1765–1769 (1975).

    Article  CAS  Google Scholar 

  42. Hughes, J., Life Sci. (in the press).

  43. Teschmacher, H., Opheim, K., Cox, B. M., and Goldstein, A., Life Sci., 16, 1771–1776 (1975).

    Article  Google Scholar 

  44. Satoh, M., Zieglgansberger, F. W., and Herz, A., Brain Res., 82, 378–382 (1974).

    Article  CAS  Google Scholar 

  45. Cochin, J., Fedn Proc., 29, 19–27 (1974).

    Google Scholar 

  46. Collier, H. O. J., Adv. Drug Res., 3, 171–188 (1966).

    Google Scholar 

  47. Goldstein, D. B., and Goldstein, A., Biochem. Pharmac., 8, 48 (Abstr. No. 152) (1961).

    Article  Google Scholar 

  48. Shuster, L., Nature, 189, 314–315 (1961).

    Article  ADS  CAS  Google Scholar 

  49. Martin, W. R., Fedn Proc., 29, 13–18 (1970).

    CAS  Google Scholar 

  50. Klee, W. A., and Streaty, R. A., Nature, 248, 61–63 (1974).

    Article  ADS  CAS  Google Scholar 

  51. Klee, W. A., and Nirenberg, M., Proc. natn. Acad. Sci. U.S.A., 71, 3474–3477 (1974).

    Article  ADS  CAS  Google Scholar 

  52. Sharma, S. K., Nirenberg, M., and Klee, W. A., Proc. natn. Acad. Sci. U.S.A., 72, 590–594 (1974).

    Article  ADS  Google Scholar 

  53. Traber, J., Gullis, R., and Hamprecht, B., Life Sci., 16, 1863–1868 (1975).

    Article  CAS  Google Scholar 

  54. Klee, W. A., Sharma, S. K., and Nirenberg, M., Life Sci. (in the press).

  55. Collier, H. O. J., and Roy, A. C., Nature, 248, 24–27 (1974).

    Article  ADS  CAS  Google Scholar 

  56. Collier, H. O. J., Francis, D. L., Henderson, G., and Schneider, C., Nature, 249, 471–473 (1974).

    Article  ADS  CAS  Google Scholar 

  57. Francis, D. L., Roy, A. C., and Collier, H. O. J., Life Sci., 16, 1901–1906 (1975).

    Article  CAS  Google Scholar 

Download references

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Snyder, S. Opiate receptor in normal and drug altered brain function*. Nature 257, 185–189 (1975). https://doi.org/10.1038/257185a0

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