Letter | Published:

Spontaneous lymphokine synthesis by human blood mononuclear cells

Nature volume 257, pages 144146 (11 September 1975) | Download Citation

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Abstract

LYMPHOCYTES, after antigenic stimulation, may synthesise and release biologically active soluble factors other than antibodies. These mediators were termed lymphokines by Dumonde1, and the most extensively studied and best characterised are migration inhibitory factors which can inhibit the migration of macrophages or leukocytes: this is the property used for their in vitro bioassay. Apart from antigens, various other stimuli may trigger lymphokine synthesis by lymphocytes, for example, polyclonal mitogens2, anti-immunoglobulin or membrane Fc or C3-receptor reactions3,4. Furthermore, migration inhibitory activity has been found in the long term culture supernatants of some established lymphoid and even non-lymphoid cell lines5,6. We report here that human blood mononuclear cells can, apparently without any inducing agent, produce material inhibiting migration of homologous leukocytes.

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Author information

Affiliations

  1. Public Health Laboratory, SF-40620 Jyväskylä 62, Finland

    • H. ARVILOMMI
  2. Department of Cell Biology, University of Jyväskylä, Finland

    • LIISA RÄSÄNEN

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DOI

https://doi.org/10.1038/257144a0

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