Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Spontaneous lymphokine synthesis by human blood mononuclear cells

Nature volume 257, pages 144–146 (1975)Cite this article

Abstract

LYMPHOCYTES, after antigenic stimulation, may synthesise and release biologically active soluble factors other than antibodies. These mediators were termed lymphokines by Dumonde1, and the most extensively studied and best characterised are migration inhibitory factors which can inhibit the migration of macrophages or leukocytes: this is the property used for their in vitro bioassay. Apart from antigens, various other stimuli may trigger lymphokine synthesis by lymphocytes, for example, polyclonal mitogens2, anti-immunoglobulin or membrane Fc or C3-receptor reactions3,4. Furthermore, migration inhibitory activity has been found in the long term culture supernatants of some established lymphoid and even non-lymphoid cell lines5,6. We report here that human blood mononuclear cells can, apparently without any inducing agent, produce material inhibiting migration of homologous leukocytes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Dumonde, D. C., et al., Nature, 224, 38 (1969).

    Article  ADS  CAS  Google Scholar 

  2. Pick, E., and Turk, J. L., Clin. exp. Immun., 10 (1972).

  3. Mackler, B. F., Altman, L. C., Rosenstreich, D. L., and Oppenheim, J. J., Nature, 249, 834 (1974).

    Article  ADS  CAS  Google Scholar 

  4. Wahl, S. M., Iverson, G. M., and Oppenheim, J. J., J. exp. Med., 140, 1631 (1974).

    Article  CAS  Google Scholar 

  5. Granger, G. A., et al., J. Immun., 104, 1476 (1970).

    CAS  PubMed  Google Scholar 

  6. Papageorgiou, P. S., Henley, W. L., and Glade, P. R., J. Immun., 108, 494 (1972).

    CAS  PubMed  Google Scholar 

  7. Bøyum, A., Scand. J. clin. Lab. Invest., 21, Suppl. 97 (1968).

  8. Clausen, J. E., J. Immun., 110, 546 (1973).

    CAS  PubMed  Google Scholar 

  9. Andersson, J., and Melchers, F., Progress in Immunology II, 1, 127 (1974).

    CAS  Google Scholar 

  10. Lay, W. H., Mendes, N. F., Bianco, C., and Nussenzweig, V., Nature, 230, 531 (1971).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Public Health Laboratory, SF-40620, Jyväskylä, 62, Finland

    H. ARVILOMMI

  2. Department of Cell Biology, University of Jyväskylä, Finland

    LIISA RÄSÄNEN

Authors
  1. H. ARVILOMMI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LIISA RÄSÄNEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

ARVILOMMI, H., RÄSÄNEN, L. Spontaneous lymphokine synthesis by human blood mononuclear cells. Nature 257, 144–146 (1975). https://doi.org/10.1038/257144a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/257144a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing