Letter | Published:

Spontaneous lymphokine synthesis by human blood mononuclear cells

Naturevolume 257pages144146 (1975) | Download Citation



LYMPHOCYTES, after antigenic stimulation, may synthesise and release biologically active soluble factors other than antibodies. These mediators were termed lymphokines by Dumonde1, and the most extensively studied and best characterised are migration inhibitory factors which can inhibit the migration of macrophages or leukocytes: this is the property used for their in vitro bioassay. Apart from antigens, various other stimuli may trigger lymphokine synthesis by lymphocytes, for example, polyclonal mitogens2, anti-immunoglobulin or membrane Fc or C3-receptor reactions3,4. Furthermore, migration inhibitory activity has been found in the long term culture supernatants of some established lymphoid and even non-lymphoid cell lines5,6. We report here that human blood mononuclear cells can, apparently without any inducing agent, produce material inhibiting migration of homologous leukocytes.

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  1. Public Health Laboratory, SF-40620, Jyväskylä, 62, Finland

  2. Department of Cell Biology, University of Jyväskylä, Finland



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