Letter | Published:

Rat liver microsomes catalyse covalent binding of 14C-vinyl chloride to macromolecules

Nature volume 257, pages 134135 (11 September 1975) | Download Citation

Subjects

Abstract

THE occurrence of angiosarcoma and injury of the liver in workers occupationally exposed to vinyl chloride (VC) has focused interest on the fate of VC in the organism. Jaeger et al.1 presented evidence that pretreatment of rats with phenobarbital, which induces the microsomal mixed function oxidase system of the liver, also enhances liver toxicity of VC. They suggested that VC may be transformed by this enzymic system to a reactive epoxide intermediate which has also been considered by some other authors2,3. This intermediate, according to its electrophilic properties, might interact with components of the liver cell. We present here some results which further support this theory.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , et al., Nature, 252, 724–726 (1974).

  2. 2.

    , , and , Ann. N.Y. Acad. Sci., 246. 135–148 (1975).

  3. 3.

    , Ann. N.Y. Acad. Sci., 246, 258–267 (1975).

  4. 4.

    , , and , Steroids, 22, 203–225 (1973).

  5. 5.

    , and , J. Steroid Biochem., 5, 179–184 (1974).

  6. 6.

    , and , Biochem. Pharmac., 24, 1079–1084 (1975).

  7. 7.

    , and , Naunyn-Schmiedebergs Arch. exp. Path. Pharmak., suppl., 287, R 100 (1975).

  8. 8.

    , and , FEBS Lett., 42, 183–186 (1974).

  9. 9.

    , , , and , Nature, 255, 641–643 (1975).

  10. 10.

    , , and , Pesticide Biochem. Physiol., 4, 299–312 (1974).

  11. 11.

    , Cancer Res., 30, 559–576 (1970).

  12. 12.

    , , , , and , Curr. Top. Radiat. Res., 9, 247–309 (1974).

  13. 13.

    , , and , Oxidases and Related Redox Systems, 2 (University Park Press, Baltimore, Maryland, 1973).

  14. 14.

    , , and , Int. J. Cancer, 15, 429–437 (1975).

Download references

Author information

Affiliations

  1. Institute of Toxicology, University of Tübingen, D-74 Tübingen, Wilhelmstrasse 56 and Institute of Occupational and Social Medicine, University of Cologne, D-5 Cologne 41, Josef-Stelzmann-Strasse 9, West Germany

    • H. KAPPUS
    • , H. M. BOLT
    • , A. BUCHTER
    •  & W. BOLT

Authors

  1. Search for H. KAPPUS in:

  2. Search for H. M. BOLT in:

  3. Search for A. BUCHTER in:

  4. Search for W. BOLT in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/257134a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.