Article | Published:

Genetic perturbations that reveal tertiary conformation of tRNA precursor molecules

Nature volume 257, pages 106110 (11 September 1975) | Download Citation

Subjects

Abstract

The ubiquity of tRNA-like conformations in tRNA precursors of prokaryotes provides a common structural basis for precursor recognition by the maturation enzymes. This design eliminates the need for multiple enzymes to achieve the maturation of different precursors. Moreover, the requirement of this specific conformation for maturation guards against the production of potentially deleterious mutant tRNAs.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , and , J. molec. Biol, 90, 677–689 (1974).

  2. 2.

    , and , J. theor. Biol., 39, 477–486 (1973).

  3. 3.

    , Prog. nucleic Acid Res. molec. Biol., 12, 49–85 (1972).

  4. 4.

    , et al., Nature new Biol., 246, 6–11 (1973).

  5. 5.

    , J. molec. Biol, 95, 529–547 (1975).

  6. 6.

    , , , and , Proc. natn. Acad. Sci. U.S.A., 71, 413–416 (1974).

  7. 7.

    , , and , J. molec. Biol. (in the press).

  8. 8.

    , , and , J. molec. Biol., 81, 157–171 (1973).

  9. 9.

    , , and , J. molec. Biol. (in the press).

  10. 10.

    , and , Proc. natn. Acad. Sci. U.S.A., 72, 1491–1495 (1975).

  11. 11.

    , and , Nature new Biol., 246, 165–168 (1973).

  12. 12.

    , , and , J. biol. Chem., 247, 5243–5251 (1972).

  13. 13.

    , and , Proc. natn. Acad. Sci. U.S.A., 70, 2091–2095 (1973).

  14. 14.

    , , , and , Cell, 5, 389–400 (1975).

  15. 15.

    , , , , and , Nucleic Acids Res., 1, 355–371 (1974).

  16. 16.

    , and , Nature new Biol., 233, 35–39 (1971).

  17. 17.

    , , and , J. biol. Chem., 248, 6348–6365 (1973).

Download references

Author information

Affiliations

  1. Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706

    • William H. McClain
    •  & J. G. Seidman

Authors

  1. Search for William H. McClain in:

  2. Search for J. G. Seidman in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/257106a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.