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Stimulation of hepatocytes and lymphocytes in vitro by liver regeneration

Nature volume 257, pages 53–54 (1975)Cite this article

Abstract

WE have reported the presence of serum factor triggering DNA synthesis in partially hepatectomised rats, using a parabiosis with direct aortic cross circulation1. The finding was subsequently confirmed with experiments both in vivo2 and in vitro3. We have also reported that partial hepatectomy stimulated function of lymphoid tissues and increased the number of antibody-forming cells in the spleen of rats immunised with sheep red blood cells4. It was then not certain how hepatectomy modifies the immune reaction, but now we present evidence that the humoral factor stimulates both hepatocytes and lymphocytes in culture.

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References

  1. Sakai, A., Nature, 228, 1186 (1970).

    Article  ADS  CAS  Google Scholar 

  2. Fisher, B., Szuch, P., Levine, M., and Fisher, E. R., Science, 171, 575 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Paul, D., Leffert, H., Sato, G., and Holley, R. W., Proc. natn. Acad. Sci., U.S.A., 69, 374 (1972).

    Article  ADS  CAS  Google Scholar 

  4. Sakai, A., Crevon, M., Sonsino, M., and Dormont, J., in Morphological and Functional Aspects of Immunity (edit. by Lindahl-Kiessling, K., Arm, G., and Hanna, M. G.), 603 (Plenum, New York 1971).

    Book  Google Scholar 

  5. Higgins, G. H., and Anderson, R. M., Archs Pathol., 12, 186 (1931).

    Google Scholar 

  6. Bucher, N. L. R., Scott, J. F., and Aub, J. C., Cancer Res. 11, 457 (1951).

    PubMed  CAS  Google Scholar 

  7. Glinos, A. D., and Grey, G. O., Proc. Soc. exp. Biol. Med., 80, 421 (1952).

    Article  CAS  Google Scholar 

  8. Demetriou, A. A., Seifter, E., and Levenson, S. M., Surgery, 76, 779 (1974).

    PubMed  CAS  Google Scholar 

  9. Craddock, C. G., Nakai, G. S., Fuckuta, H., and Vanslager, L. M., J. exp. Med., 120, 389 (1964).

    Article  CAS  Google Scholar 

  10. Sakai, A., Muller-Berat, C. N., Debray-Sachs, M., and Crevon, M. C., Acta Path. Microbiol. Scand. 78, 652 (1970).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, New York, 11203

    A. SAKAI & S. L. KOUNTZ

Authors
  1. A. SAKAI
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  2. S. L. KOUNTZ
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SAKAI, A., KOUNTZ, S. Stimulation of hepatocytes and lymphocytes in vitro by liver regeneration. Nature 257, 53–54 (1975). https://doi.org/10.1038/257053a0

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