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Stimulation of hepatocytes and lymphocytes in vitro by liver regeneration

Naturevolume 257pages5354 (1975) | Download Citation



WE have reported the presence of serum factor triggering DNA synthesis in partially hepatectomised rats, using a parabiosis with direct aortic cross circulation1. The finding was subsequently confirmed with experiments both in vivo2 and in vitro3. We have also reported that partial hepatectomy stimulated function of lymphoid tissues and increased the number of antibody-forming cells in the spleen of rats immunised with sheep red blood cells4. It was then not certain how hepatectomy modifies the immune reaction, but now we present evidence that the humoral factor stimulates both hepatocytes and lymphocytes in culture.

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  1. 1

    Sakai, A., Nature, 228, 1186 (1970).

  2. 2

    Fisher, B., Szuch, P., Levine, M., and Fisher, E. R., Science, 171, 575 (1971).

  3. 3

    Paul, D., Leffert, H., Sato, G., and Holley, R. W., Proc. natn. Acad. Sci., U.S.A., 69, 374 (1972).

  4. 4

    Sakai, A., Crevon, M., Sonsino, M., and Dormont, J., in Morphological and Functional Aspects of Immunity (edit. by Lindahl-Kiessling, K., Arm, G., and Hanna, M. G.), 603 (Plenum, New York 1971).

  5. 5

    Higgins, G. H., and Anderson, R. M., Archs Pathol., 12, 186 (1931).

  6. 6

    Bucher, N. L. R., Scott, J. F., and Aub, J. C., Cancer Res. 11, 457 (1951).

  7. 7

    Glinos, A. D., and Grey, G. O., Proc. Soc. exp. Biol. Med., 80, 421 (1952).

  8. 8

    Demetriou, A. A., Seifter, E., and Levenson, S. M., Surgery, 76, 779 (1974).

  9. 9

    Craddock, C. G., Nakai, G. S., Fuckuta, H., and Vanslager, L. M., J. exp. Med., 120, 389 (1964).

  10. 10

    Sakai, A., Muller-Berat, C. N., Debray-Sachs, M., and Crevon, M. C., Acta Path. Microbiol. Scand. 78, 652 (1970).

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  1. Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, New York, 11203

    • A. SAKAI
    •  & S. L. KOUNTZ


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