Letter | Published:

Stimulation of hepatocytes and lymphocytes in vitro by liver regeneration

Nature volume 257, pages 5354 (04 September 1975) | Download Citation

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Abstract

WE have reported the presence of serum factor triggering DNA synthesis in partially hepatectomised rats, using a parabiosis with direct aortic cross circulation1. The finding was subsequently confirmed with experiments both in vivo2 and in vitro3. We have also reported that partial hepatectomy stimulated function of lymphoid tissues and increased the number of antibody-forming cells in the spleen of rats immunised with sheep red blood cells4. It was then not certain how hepatectomy modifies the immune reaction, but now we present evidence that the humoral factor stimulates both hepatocytes and lymphocytes in culture.

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References

  1. 1.

    , Nature, 228, 1186 (1970).

  2. 2.

    , , , and , Science, 171, 575 (1971).

  3. 3.

    , , , and , Proc. natn. Acad. Sci., U.S.A., 69, 374 (1972).

  4. 4.

    , , , and , in Morphological and Functional Aspects of Immunity (edit. by Lindahl-Kiessling, K., Arm, G., and Hanna, M. G.), 603 (Plenum, New York 1971).

  5. 5.

    , and , Archs Pathol., 12, 186 (1931).

  6. 6.

    , , and , Cancer Res. 11, 457 (1951).

  7. 7.

    , and , Proc. Soc. exp. Biol. Med., 80, 421 (1952).

  8. 8.

    , , and , Surgery, 76, 779 (1974).

  9. 9.

    , , , and , J. exp. Med., 120, 389 (1964).

  10. 10.

    , , , and , Acta Path. Microbiol. Scand. 78, 652 (1970).

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Author information

Affiliations

  1. Department of Surgery, Downstate Medical Center, State University of New York, Brooklyn, New York 11203

    • A. SAKAI
    •  & S. L. KOUNTZ

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DOI

https://doi.org/10.1038/257053a0

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