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How specific are nuclear “receptors” for thyroid hormones?

Nature volume 257, pages 1823 (04 September 1975) | Download Citation

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Abstract

The presence of “high-affinity-saturable” binding sites for thyroid hormones of similar characteristics not only in isolated nuclei but in all the major extranuclear cellular components, as well as the failure of cytosol to promote nuclear binding, invalidates the analogy with steroid hormone receptors and necessitates a more critical assessment of the Physiological relevance of current approaches to binding of thyroid hormone in vitro to nuclear preparations.

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Affiliations

  1. National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

    • J. R. Tata

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https://doi.org/10.1038/257018a0

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