Article | Published:

How specific are nuclear “receptors” for thyroid hormones?

Naturevolume 257pages1823 (1975) | Download Citation

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  • A Corrigendum to this article was published on 29 January 1976

Abstract

The presence of “high-affinity-saturable” binding sites for thyroid hormones of similar characteristics not only in isolated nuclei but in all the major extranuclear cellular components, as well as the failure of cytosol to promote nuclear binding, invalidates the analogy with steroid hormone receptors and necessitates a more critical assessment of the Physiological relevance of current approaches to binding of thyroid hormone in vitro to nuclear preparations.

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  1. National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    • J. R. Tata

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https://doi.org/10.1038/257018a0

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