Abstract
The presence of “high-affinity-saturable” binding sites for thyroid hormones of similar characteristics not only in isolated nuclei but in all the major extranuclear cellular components, as well as the failure of cytosol to promote nuclear binding, invalidates the analogy with steroid hormone receptors and necessitates a more critical assessment of the Physiological relevance of current approaches to binding of thyroid hormone in vitro to nuclear preparations.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cuatrecasas, P., Biochem. Pharmac., 23, 2353–2361 (1974).
King, R. J. B., and Mainwaring, W. I. P., Steroid–Cell Interations (Butterworths London, 1974).
Jensen, E. V., and De Sombre, E. R., Science, 182, 126–134 (1973).
O'Malley, B. W., and Means, A. R. (eds), Receptors for Reproductive Hormones (Plenum, New York, 1973).
O'Malley, B. W., et al., Rec. Prog. Hormone Res., 25, 105–153 (1969).
Baulieu, E.-E., et al., Rec. Prog. Hormone Res., 27, 351–412 (1971).
Liao, S., and Fang, S., Vitamins and Hormones, 27, 17–90 (1969).
Tomkins, G. M., Harvey Lectures, 68, 37–65 (1974).
Tata, J. R., and Widnell, C. C., Biochem. J., 98, 604–620 (1966).
Tata, J. R., Handbook of Physiology, Section 7, 111, 469–478 (1974).
Tata, J. R., Prog. Nucleic Acid Res., 5, 191–250 (1966).
Tata, J. R., in Biochemical Actions of Hormones, 1 (edit. by Litwack, G.), 89–133 (Academic, New York, 1970).
Oppenheimer, J. H., Koerner, D., Schwartz, H. L., and Surks, M. I., J. clin. Endocr. Metab., 35, 330–333 (1972).
Surks, M. I., Koerner, D., Dillman, S., and Oppenheimer, J. H., J. biol. Chem., 248, 7066–7072 (1973).
Koerner, D., Surks, M. I., and Oppenheimer, J. H., J. clin. Endocr. Metab., 38, 706–709 (1974).
Oppenheimer, J. H., Schwartz, H. L., Koerner, D., and Surks, M. I., J. clin. Invest., 53, 768–777 (1974).
Surks, M. I., Koerner, D., and Oppenheimer, J. H., J. clin. Invest., 55, 50–60 (1975).
De Groot, L. J., and Torresani, J., Endocrinology, 96, 357–369 (1975).
Samuels, H. H., and Tsai, J. S., Proc. natn. Acad. Sci. U.S.A., 70, 3488–3492 (1973).
Samuels, H. H., Tsai, J. S., and Casanova, J., Science, 184, 1188–1191 (1974).
De Groot, L. J., Refetoff, S., Strausser, J., and Barsano, C., Proc. natn. Acad. Sci. U.S.A., 71, 4042–4046 (1974).
Thomopoulos, P., Dastugue, B., and Defer, N., Biochem. biophys. Res. Commun., 58, 499–506 (1974).
MacLeod, K. M., and Baxter, J. D., Biochem. biophys. Res. Commun., 62, 577–583 (1975).
Tata, J. R., Biochim. biophys. Acta, 28, 91–94 (1958).
Lissitzky, S., Roques, M., and Benevent, M. T., Biochim. biophys. Acta, 41, 252–263 (1960).
Tapley, D. F., and Basso, N., Biochem. biophys. Acta, 36, 486–498 (1959).
Tata, J. R., Ernster, L., and Suranyi, E. M., Biochem. biophys. Acta, 60, 461–479 and 480–491 (1962).
Tata, J. R., Rec. Prog. Hormone Res., 18, 221–259 (1962).
Sufi, S. B., Tocafondi, R. S., Malan, P. G., and Ekins, R. P., J. Endocr., 58, 41–52 (1973).
Davis, P. J., Handwerger, B. S., and Glaser, F., J. biol. Chem., 249, 6208–6219 (1974).
Dillman, W., Surks, M. I., and Oppenheimer, J. H., Endocrinology, 95, 492–498 (1974).
Sterling, K., Saldhana, V. F., Brenner, M. A., and Milch, P. O., Nature, 250, 661–663 (1974).
Santi, D. V., et al., Biochemistry, 12, 2412–2416 (1973).
Blobel, G., and Potter, V. R., Science, 154, 1662–1665 (1966).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).
Fleck, A., and Munro, H. N., Biochim. Biophys. Acta, 55, 571–583 (1962).
Burton, K., Biochem. J., 62, 315–352 (1956).
Oppenheimer, J. H., Schwartz, H. L., and Surks, M. I., Endocrinology, 95, 897–903 (1974).
Rousseau, G. G., Baxter, J. D., Higgins, S. J., and Tomkins, G. M., J. molec. Biol., 79, 539–554 (1973).
Charles, M. A., Ryffel, G. U., Obinata, M., McCarthy, B. J., and Baxter, J. D., Proc. natn. Acad. Sci. U.S.A., 72, 1787–1791 (1975).
Wisher, M. H., and Evans, W. H., Biochem. J., 146, 375–388 (1975).
Roodyn, D. B., in Enzyme Cytology (edit. by Roodyn, D. B.), 103–180, (Academic, New York, 1967).
Greenawalt, J. W., Meth. in Enzymol., 31, part A, 310–323 (1974).
Bergeron, J. J. M., and Lanoix, J., J. Cell biol. (in the press).
Elgin, S. C. R., Froehner, S. C., Smart, J. E., and Bonner, J., Adv. cell molec. Biol., 1, 1–57 (1971).
Tata, J. R., and Baker, B., Expl Cell Res., 83, 111–124 (1974).
Edelman, I. S., and Fimognari, G. M., Rec. Prog. Hormone Res., 24, 1–33 (1968).
Wilson, J. D., and Glovna, R. E., Rec. Prog. Hormone Res., 26, 309–336 (1970).
Woeber, K. A., and Ingbar, S. H., Handbook of Physiology, section 7, 3, 187–196 (1974).
Pons, A.-M., Lucas, M., Roman, M.-V., and Michel, R., C. r.hebd. Séanc. Acad. Sci. Paris, 279, 517–520 (1974).
Alberga, A., Massol, N., Raynaud, J.-P., and Baulieu, E.-E., Biochemistry, 10, 3835–3843 (1971).
Yamamoto, K. R., and Alberts, B., Cell, 4, 301–310 (1975).
Jackson, V., and Chalkley, R., J. biol. Chem., 249, 1615–1626 (1974).
Jackson, V., and Chalkley, R., J. biol. Chem., 249, 1627–1636 (1974).
Robel, P., Blondeau, J.-P., and Baulieu, E.-E., Biochim. biophys. Acta, 373, 1–9 (1974).
Tata, J. R., Nature, 219, 331–337 (1968).
Herschko, A., Mamont, P., Shields, R., and Tomkins, G. M., Nature, 232, 206–211 (1971).
Robison, G. A., Butcher, R. W., and Sutherland, E. W., Cyclic AMP (Academic, New York, 1974).
Bullock, L. P., Bardin, C. W., and Ohno, S., Biochem. biophys. Res. Commun., 44, 1537–1543 (1971).
Sibley, C. H., and Tomkins, G. M., Cell, 2, 221–227 (1974).
Author information
Authors and Affiliations
Additional information
The erratum article can be found online at https://doi.org/10.1038/259346b0
Rights and permissions
About this article
Cite this article
Tata, J. How specific are nuclear “receptors” for thyroid hormones?. Nature 257, 18–23 (1975). https://doi.org/10.1038/257018a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/257018a0
This article is cited by
-
Effect of methimazole-induced hypothyroidism on alveolar macrophages
Virchows Archiv B Cell Pathology Including Molecular Pathology (1991)
-
Thyroid hormone action on intermediary metabolism
Klinische Wochenschrift (1984)
-
In vitro binding of triiodothyronine to rat liver mitochondria
Pfl�gers Archiv European Journal of Physiology (1981)
-
Investigations on myelination in vitro: Thyroid hormone receptors in cultures of cells dissociated from embryonic mouse brain
Bioscience Reports (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.