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Synthesis and conformations of hypothalamic hormone releasing factors: two QRF-analogues containing backbone N-methyl groups

Nature volume 256, pages 750–751 (1975)Cite this article

A Corrigendum to this article was published on 09 October 1975

An Erratum to this article was published on 01 September 1975

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Abstract

SINCE its isolation and characterisation1,2, the hypothalamic hormone-releasing factor TRF (pGlu–His–Pro–NH2) has been the subject of several conformational studies. Most investigations have indicated that the steric characteristics of the three adjacent rings strongly limit the backbone conformational flexibility and support a preference for an extended structure. The importance of each functional group in the molecule in terms of biological potency has been systematically investigated (for review, see ref. 3). With one exception (methylation of the histidyl side chain in the Nτ position) all the chemical modifications which have been made to date were accompanied by a substantial loss of biological activity. We have shown4 that most of these modifications do not significantly affect the preferred backbone conformation of the hormone, emphasising the critical role of each functional group in TRF for optimal binding to the receptor sites.

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  • 01 September 1975

    The title of the article (Nature, 256, 750; 1975) by B. Donzel et al. should have read "Synthesis and conformations of hypothalamic hormone releasing factors: two TRF-analogues containing backbone N-methyl groups" and not as printed.

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Authors and Affiliations

  1. Department of Chemistry, University of California, San Diego, La Jolla, California, 92037

    B. DONZEL & M. GOODMAN

  2. The Salk Institute for Biological Studies, La Jolla, California, 92037

    J. RIVIER, N. LING & W. VALE

Authors
  1. B. DONZEL
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  2. M. GOODMAN
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  3. J. RIVIER
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  4. N. LING
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  5. W. VALE
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DONZEL, B., GOODMAN, M., RIVIER, J. et al. Synthesis and conformations of hypothalamic hormone releasing factors: two QRF-analogues containing backbone N-methyl groups. Nature 256, 750–751 (1975). https://doi.org/10.1038/256750a0

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