Letter | Published:

Occurrence of “pockets” of very small cells in adipose tissue of the guinea pig

Naturevolume 256pages723724 (1975) | Download Citation

Subjects

Abstract

THE concept of hyperplastic obesity, wherein the excessive number of cells in the adipose depots is thought to originate during overnutrition in early life, has evolved in the laboratories of Hirsch1, Salans2 and Björntorp3. The estimation of the number of adipose cells relies on (1) a measurement of total body fat and (2) a measure of the mean cell size. The two methods most commonly used for measurement of cell size are based on the microscopic examination of cells in a piece of fixed tissue4, or on sorting of cells in to size ranges by an electronic cell counter after dispersion of the tissue into a free cell suspension5.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Hirsch, J., and Knittle, J. L., Fedn Proc., 29, 1516–1521 (1970).

  2. 2

    Salans, L. B., Cushman, S. W., and Weismann, R. E., J. clin. Invest., 52, 929–941 (1973).

  3. 3

    Björntorp, P., and Sjöström, L., Metabolism, 20, 703–713 (1971).

  4. 4

    Sjöström, L., Björntorp, P., and Vrána, J., J. Lipid Res., 12, 521–530 (1971).

  5. 5

    Hirsch, J., and Gallian, E., J. Lipid Res., 9, 110–119 (1968).

  6. 6

    Lemmonier, D., J. clin. Invest., 51, 2907–2915 (1972).

  7. 7

    Ashwell, M. A., Priest, P., and Sowter, C., Nature, 256, 724–725 (1975).

Download references

Author information

Affiliations

  1. Division of Nutrition and Agriculture, Unilever Research Laboratory, Colworth House, Sharnbrook, Bedford, MK44 1LQ, UK

    • JANET KIRTLAND
    • , MICHAEL I. GURR
    •  & GEOFFREY SAVILLE
  2. Department of Investigative Medicine, Cambridge, CB2 1QN, UK

    • ELSIE M. WIDDOWSON

Authors

  1. Search for JANET KIRTLAND in:

  2. Search for MICHAEL I. GURR in:

  3. Search for GEOFFREY SAVILLE in:

  4. Search for ELSIE M. WIDDOWSON in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/256723a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.