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Occurrence of “pockets” of very small cells in adipose tissue of the guinea pig

Nature volume 256, pages 723–724 (1975)Cite this article

Abstract

THE concept of hyperplastic obesity, wherein the excessive number of cells in the adipose depots is thought to originate during overnutrition in early life, has evolved in the laboratories of Hirsch1, Salans2 and Björntorp3. The estimation of the number of adipose cells relies on (1) a measurement of total body fat and (2) a measure of the mean cell size. The two methods most commonly used for measurement of cell size are based on the microscopic examination of cells in a piece of fixed tissue4, or on sorting of cells in to size ranges by an electronic cell counter after dispersion of the tissue into a free cell suspension5.

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Authors and Affiliations

  1. Division of Nutrition and Agriculture, Unilever Research Laboratory, Colworth House, Sharnbrook, Bedford, MK44 1LQ, UK

    JANET KIRTLAND, MICHAEL I. GURR & GEOFFREY SAVILLE

  2. Department of Investigative Medicine, Cambridge, CB2 1QN, UK

    ELSIE M. WIDDOWSON

Authors
  1. JANET KIRTLAND
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  2. MICHAEL I. GURR
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  3. GEOFFREY SAVILLE
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  4. ELSIE M. WIDDOWSON
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KIRTLAND, J., GURR, M., SAVILLE, G. et al. Occurrence of “pockets” of very small cells in adipose tissue of the guinea pig. Nature 256, 723–724 (1975). https://doi.org/10.1038/256723a0

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  • DOI: https://doi.org/10.1038/256723a0

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