Letter | Published:

Symmetry recognition hypothesis model for tRNA binding to aminoacyl-tRNA synthetase

Naturevolume 256pages679681 (1975) | Download Citation

Subjects

Abstract

THE fidelity of the transfer of the genetic information at the translational level depends largely on the accuracy with which each transfer RNA (tRNA) is aminoacylated by its cognate synthetase. The search for the common sites on tRNA which the enzyme recognises has resulted so far in a rather confusing picture. Practically all parts of the tRNA molecule have been implicated as the possible recognition site(s)1,2.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Kisselev, L. L., and Favorova, O. O., Adv. Enzymol., 40, 141 (1974).

  2. 2

    Söll, D., and Schimmel, P. R., Enzymes, 10, 489 (1974).

  3. 3

    Kim, S. H., et al., Proc. natn. Acad. Sci. U.S.A., 71, 4970 (1974).

  4. 4

    Kula, M.-R., FEBS Lett., 35, 299 (1973).

  5. 5

    Koch, G. L. E., Boulanger, Y., and Hartley, B. S., Nature, 249, 316 (1974).

  6. 6

    Waterson, R. M., and Konigsberg, W. H., Proc. natn. Acad. Sci. U.S.A., 71, 376 (1974).

  7. 7

    Bruton, C. J., Jakes, R., and Koch, G. L. E., FEBS Lett., 45, 26 (1974).

  8. 8

    Kim, S. H., et al., Science, 179, 285 (1973).

  9. 9

    Kim, S. H., Science, 185, 435 (1974).

  10. 10

    Robertus, J. D., et al., Nature, 250, 546 (1974).

  11. 11

    Poljak, R. J., et al., Proc. natn. Acad. Sci. U.S.A., 70, 3305 (1973).

  12. 12

    Mathews, B. W., J. molec. Biol., 33, 491 (1968).

  13. 13

    Roe, B., Sirover, M., and Dudock, B., Biochemistry, 12, 4146 (1973).

  14. 14

    Giegé, R., et al., Eur. J. Biochem., 45, 351 (1974).

  15. 15

    Ghysen, A., and Cellis, J. E., J. molec. Biol., 83, 333 (1974).

  16. 16

    Anderson, K. W., and Smith, J. D., J. molec. Biol., 69, 349 (1972).

  17. 17

    Yaniv, M., Folk, W. R., and Berg, P., J. molec. Biol., 86, 245 (1974).

Download references

Author information

Affiliations

  1. Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, 27710

    • SUNG-HOU KIM

Authors

  1. Search for SUNG-HOU KIM in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/256679a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.