Letter | Published:

Evidence that sensory axons are mitogenic for Schwann cells

Naturevolume 256pages662664 (1975) | Download Citation

Subjects

Abstract

WE have obtained preparations of peripheral nerve tissue in culture which provide either Schwann cell populations, essentially free of connective tissue cells such as fibroblasts, or outgrowing neurites from sensory (or autonomic) ganglia entirely free of ensheathing Schwann cells or connective tissue elements. Thus, these two major elements of peripheral nerve can be studied and characterised separately or in recombination. We report here that the ‘bare’ sensory ganglion neurite provides a potent stimulus for thymidine incorporation and mitosis in Schwann cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fischbach, G. D., Devl Biol., 28, 407 (1972).

  2. 2

    Bunge, R., Rees, R., Wood, P., Burton, H., and Ko, C.-P., Brain Res., 66, 401 (1974).

  3. 3

    Murray, M., and Stout, A. P., Am. J. Path., 16, 41 (1940).

  4. 4

    Bunge, R. P., and Wood, P. M., Brain Res., 57, 261 (1973).

  5. 5

    Causey, G., The Cell of Schwann (Livingston, Edinburgh and London, 1960).

  6. 6

    Thomas, P. K., J. Anat., 106, 463 (1970).

  7. 7

    Stirling, C. A., Brain Res., 87, 130 (1975).

  8. 8

    Logan, J. E., Rossiter, R. J., and Barr, M. L., J. Anat., 87, 419 (1953).

Download references

Author information

Affiliations

  1. Department of Anatomy, Washington University School of Medicine, St Louis, Missouri, 63110

    • PATRICK M. WOOD
    •  & RICHARD P. BUNGE

Authors

  1. Search for PATRICK M. WOOD in:

  2. Search for RICHARD P. BUNGE in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/256662a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.