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Mouse T-cell surface glycoprotein recognised by heterologous anti-thymocyte sera and its relationship to Thy-1 antigen

Naturevolume 256pages652654 (1975) | Download Citation

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Abstract

CELL surface proteins specific for either T or B lymphocytes probably have a significant role in lymphocyte physiology, and we have therefore been characterising the plasma membrane proteins from mouse lymphocytes to identify such molecules and to determine their function. We have previously detected a high molecular weight T-cell-surface protein (T200, apparent molecular weight 200,000) which could be labelled by lactoperoxidase-catalysed iodination1 and was recognised by rabbit anti-mouse thymocyte sera (ATS). We have now identified a low molecular weight T-cell-specific molecule present on mouse thymocytes, T lymphomas and peripheral T cells which is also recognised by rabbit antibodies to mouse lymphocytes.

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Affiliations

  1. The Salk Institute for Biological Studies, PO Box 1809, San Diego, California, 92112

    • IAN S. TROWBRIDGE
    • , IRVING L. WEISSMAN
    •  & MICHAEL J. BEVAN

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https://doi.org/10.1038/256652a0

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