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Serological identification of HL-A-linked human ‘Ia-type’ antigens

Naturevolume 256pages650652 (1975) | Download Citation

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Abstract

THE Ir genetic region of the mouse which lies between the H-2K and H-2D loci that control the original serologically detectable H-2 specificities, has also been shown to contain genes controlling a new set of serological specificities called Ia for immune associated. Antisera raised by cross immunisation between H-2 recombinant strains have been shown to recognise the products of several genes within the Ir region (reviewed in ref. 1). Unlike the H-2K and H-2D antigens the Ia antigens have a tissue distribution that often does not include T lymphocytes.

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References

  1. 1

    Schreffler, D. C., and David, C. S., Adv. Immun., 20, 125–195 (1975).

  2. 2

    van Leeuwen, A., van Schmit, H. R. E., and van Rood, J. J., Transplant. Proc., V, 1539–1541 (1973).

  3. 3

    Legrand, L., and Dausset, J., Transplant. Proc., VII, No. 1, 5–8 (1975).

  4. 4

    Ceppellini, R., et al., Transplant. Proc., III, No. 1 58–70 (1971).

  5. 5

    van Leeuwen, A., Schmit, H. R. E., and van Rood, J. J., Transplant. Proc., V, No. 4, 1539 (1973).

  6. 6

    Patengale, P. K., Smith, R. W., and Gerber, P., Lancet, ii, 93–94 (1973).

  7. 7

    Bernoco, D., et al., Folio Haemat., 54, 795–812 (1969).

  8. 8

    Dick, H. M., Steel, C. M., and Crichton, W. B., Tissue Antigens, 2, 85–93 (1972).

  9. 9

    Jeannet, M., and Alberto, P., Schweiz. Med. Wschr., 102, 1170–1172 (1972).

  10. 10

    Walford, R. L., Waters, H., Smith, G. S., and Sturgeon, P., Tissue Antigens, 3, 222–233 (1973).

  11. 11

    Cullen, P. R., and Mason, D. Y., Clin. exp. Immun., 17, 571–586 (1974).

  12. 12

    Pious, D., Bodmer, J. G., and Bodmer, W. F., Tissue Antigens, 4, 247–256 (1974).

  13. 13

    Bodmer, W. F., in Histocompatibility Testing, 1972 (edit. by Dausset, J., and Colombani, J.), 611–617 (Munksgaard, Copenhagen, 1973).

  14. 14

    Orkin, S. H., Buchanen, P. D., Yount, W. J., Reisner, H., and Littlefield, J. W., Proc. natn. Acad. Sci. U.S.A., 70, 2401–2405 (1973).

  15. 15

    Klein, E., et al., Cancer Res., 28, 1300–1310 (1968).

  16. 16

    Goodfellow, P. N., et al., Nature, 254, 267–269 (1975).

  17. 17

    Allderdice, P. N., et al., Cell Sci., 12, 263–274 (1973).

  18. 18

    Lamm, L. U., et al., Hum. Hered., 24, 273–277 (1974).

  19. 19

    Bernoco, D., Cullen, S., Scudeller, G., Trinchieri, G., and Ceppellini, R., in Histocompatibility Testing, 1972 (edit. by Dausset, J., and Colombani, J.), 527–537 (Munksgaard, Copenhagen, 1973).

  20. 20

    McDevitt, H. O., and Bodmer, W. F., Lancet, ii, 1269–1275 (1974).

  21. 21

    HL-A and disease, Transplant. Rev., 22 (1975).

  22. 22

    Jersild, C., Dupont, B., Fogh, T., Platz, P. J., and Svejgaard, A., Transplant. Rev., 22, 148–163 (1975).

  23. 23

    Winchester, R. J., et al., J. exp. Med., 141, 924–929 (1975).

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Affiliations

  1. Genetics Laboratory, Department of Biochemistry, University of Oxford, Oxford, UK

    • E. A. JONES
    • , P. N. GOODFELLOW
    • , J. G. BODMER
    •  & W. F. BODMER

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https://doi.org/10.1038/256650a0

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