Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Isolation of infectious C-type oncornavirus from human leukaemic bone marrow cells

Nature volume 256, pages 595–597 (1975)Cite this article

Abstract

C-TYPE ONCORNAVIRUSES are associated with neoplasms of the haemopoietic organs in several vertebrate species1. Molecular hybridisation studies have revealed the presence of an RNA species in human leukaemias that has some homology with animal C-type oncornaviruses2,3. In addition, leukaemic cells contain a reverse transcriptase that proves to be serologically closely related to the enzyme from the woolly monkey C-type oncornavirus4. Several claims have been made for the presence of C-type particles in malignant cells or plasma of leukaemic patients (for review, see ref. 5). There have also been reports of release of such virus particles in tissue culture lines of leukaemic cells6,7.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Tooze, J., The Molecular Biology of Tumor Viruses (Cold Spring Harbor, 1974).

    Google Scholar 

  2. Hellmann, R., Kufe, D., and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 69, 435–439 (1972).

    Article  ADS  Google Scholar 

  3. Gallo, R. C., Miller, N. R., Saxinger, W. C., and Gillespie, D., Proc. natn. Acad. Sci. U.S.A., 70, 3219–3224 (1973).

    Article  ADS  CAS  Google Scholar 

  4. Todaro, G., and Gallo, R. C., Nature, 244, 206–209 (1973).

    Article  ADS  CAS  Google Scholar 

  5. Hirshaut, Y., Reagan, R. L., Perry, S., De Vita, V., Jr, and Barile, M. F., Cancer, 34, 1080–1089 (1974).

    Article  CAS  Google Scholar 

  6. Mak, T. W., Manaster, J., Howatson, A. F., McCulloch, E. A., and Till, J. E., Proc. natn. Acad. Sci. U.S.A., 71, 4336–4340 (1974).

    Article  ADS  CAS  Google Scholar 

  7. Gallagher, R. E., and Gallo, R. C., Science, 187, 350–353 (1975).

    Article  ADS  CAS  Google Scholar 

  8. Miller, M. F., Allen, P. T., and Dmochowski, L., J. gen. Virol., 21, 57–68 (1973).

    Article  CAS  Google Scholar 

  9. Klement, V., Rowe, W. P., Hartley, J. W., and Pugh, W. E., Proc. natn. Acad. Sci. U.S.A., 63, 753–758 (1969).

    Article  ADS  CAS  Google Scholar 

  10. Niwa, O., Declève, A., Lieberman, M., and Kaplan, H. S., J. Virol., 12, 68–73 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Zurcher, C., Brinkhof, J., Bentvelzen, P., and De Man, J. C. H., Nature, 254, 457–459 (1975).

    Article  ADS  CAS  Google Scholar 

  12. Rockwell, S. C., Kallman, R. F., and Fajardo, L. F., J. natn. Cancer Inst., 49, 735–750 (1972).

    CAS  Google Scholar 

  13. Strand, M., and August, J. T., J. biol. Chem., 248, 5627–5633 (1973).

    CAS  PubMed  Google Scholar 

  14. Fleissner, E., et al., Cold Spring Harb. Symp. quant. Biol., 39, 1057–1066 (1975).

    Article  Google Scholar 

  15. Grollé, P. F., Bentvelzen, P., and Van Noord, M. J., Biomédicine, 19, 148–151 (1973).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radiobiological Institute TNO, Rijswijk ZH, The Netherlands

    K. NOOTER, A. M. AARSSEN & P. BENTVELZEN

  2. Institute for Experimental Gerontology TNO, Rijswijk ZH, The Netherlands

    F. G. DE GROOT & FRIDA G. VAN PELT

Authors
  1. K. NOOTER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. AARSSEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. BENTVELZEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. G. DE GROOT
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. FRIDA G. VAN PELT
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

NOOTER, K., AARSSEN, A., BENTVELZEN, P. et al. Isolation of infectious C-type oncornavirus from human leukaemic bone marrow cells. Nature 256, 595–597 (1975). https://doi.org/10.1038/256595a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/256595a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing