Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Genetic control of cell size at cell division in yeast

Abstract

A temperature-sensitive mutant strain of the fission yeast Schizosaccharomyces pombe has been isolated which divides at half the size of the wild type. Study of this strain suggests that there is a cell size control over DNA synthesis and a second control acting on nuclear division.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Schaechter, M., Williamson, J. P., Hood, J. R., and Koch, A. L., J. gen. Microbiol., 29, 421–434 (1962).

    Article  CAS  Google Scholar 

  2. Mitchison, J. M., and Creanor, J., Expl Cell Res., 67, 368–374 (1971).

    Article  CAS  Google Scholar 

  3. Killander, D., and Zetterberg, A., Expl Cell Res., 38, 272–284 (1965); 40, 12–20 (1965).

    Article  CAS  Google Scholar 

  4. Fantes, P. A., Grant, W. D., Pritchard, R. H., Sudbery, P. E., and Wheals, A. E., J. theor. Biol, 50, 213–244 (1975).

    Article  CAS  Google Scholar 

  5. Mitchison, J. M., in Methods in Cell Physiology (edit. by Prescott, D. M.), 4, 131–165 (Academic, New York, 1970).

    Google Scholar 

  6. Mitchison, J. M., and Creanor, J., Expl Cell Res., 69, 244–247 (1971).

    Article  CAS  Google Scholar 

  7. Halvorson, H. O., Carter, B. L. A., and Tauro, P., Methods in Enzymology, 21, 462–471 (1970).

    Article  Google Scholar 

  8. James, T. W., in Cell Cycle Controls (edit. by Padilla, G. M., Cameron, I. L., and Zimmerman, A.), 31–42 (Academic, New York, 1974).

    Google Scholar 

  9. Stebbing, N., J. Cell Sci., 9, 701–717 (1971).

    CAS  PubMed  Google Scholar 

  10. Culotti, J., and Hartwell, L. H., Expl Cell Res., 67, 389–401 (1971).

    Article  CAS  Google Scholar 

  11. Hartwell, L. H., Bact. Rev., 38, 164–198 (1974).

    CAS  PubMed  Google Scholar 

  12. Bostock, C. J., Expl Cell Res., 60, 16–26 (1970).

    Article  CAS  Google Scholar 

  13. Donachie, W. D., Jones, N. C., and Teather, R., Symp. Soc. gen. Microbiol., 23, 9–44 (1973).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nurse, P. Genetic control of cell size at cell division in yeast. Nature 256, 547–551 (1975). https://doi.org/10.1038/256547a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/256547a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing