Letter | Published:

Electron spin resonance measurements of molecular interactions in mouse olfactory epithelium

Naturevolume 256pages517518 (1975) | Download Citation

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Abstract

THE mechanism by which molecules interact with, and so stimulate, the surfaces of olfactory receptor cells has given rise to much speculation. Since oil-soluble substances are often very effective odours, it has been proposed that olfactory transduction occurs when an odorant molecule perturbs the lipids of the sensory membranes. Conversely, the known steric aspects of odorant molecule interactions argue for a more specific binding for which a protein would be a more suitable receptor1–4.

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References

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    Davies, J. T., in Handbook of Sensory Physiology, 4 (edit. by Beidler, L. M.), part 1, 322 (Springer, New York, 1971).

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    McConnell, H. M., and McFarland, B. G., Q. Rev. Biophys., 3, 91 (1970).

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    Roubal, W. T., Prog. Chem. Fats, 13, 63 (1972).

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    Moulton, D. G., Celebi, G., and Fink, R. P., in Taste and Smell in Vertebrates (CIBA Foundation Symposium), (edit. by Wolstenholme, G. E. W., and Knight, J.), 227–250 (Churchill, London, 1970).

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    Getchell, T. U., Getchell, M. L., Ann. N. Y. Acad. Sci., 237, 62 (1974).

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Affiliations

  1. Department of Biology, Department of Physics, Guy's Hospital Medical School, University of London, London Bridge, London, SE1 9RT, UK

    • L. H. BANNISTER
  2. Division of Biological Sciences, Department of Physics, Guy's Hospital Medical School, University of London, London Bridge, London, SE1 9RT, UK

    • A. D. CLARK
    • , L. J. DUNNE
    •  & S. J. WYARD

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https://doi.org/10.1038/256517a0

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