Letter | Published:

Human embryonic haemoglobins including a comparison by homology of the human ζ and α chains

Naturevolume 256pages511513 (1975) | Download Citation



DURING the first 10 weeks of human embryonic life, there exist unique haemoglobins designated Gower 1 and Gower 2, and it has been suggested that Hb Gower 1 is a tetramer consisting of ɛ chains (ɛ4) (ref. 1). Haemoglobin Portland has also been described in infants with developmental abnormalities2 and neonates with severe α–thalassaemia, the Bart's hydrops foetalis syndrome3,4. Hb Portland is composed of two γ chains and two ζ chains5.

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  1. H. KAMUZORA: H. K. is a Commonwealth Scholar, Churchill College, Cambridge, on study leave from the Faculty of Medicine, University of Dar-Es-Salaam, Tanzania.


  1. MRC Abnormal Haemoglobin Unit, University Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR, UK

    •  & H. LEHMANN


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