Abstract
DURING the first 10 weeks of human embryonic life, there exist unique haemoglobins designated Gower 1 and Gower 2, and it has been suggested that Hb Gower 1 is a tetramer consisting of ɛ chains (ɛ4) (ref. 1). Haemoglobin Portland has also been described in infants with developmental abnormalities2 and neonates with severe α–thalassaemia, the Bart's hydrops foetalis syndrome3,4. Hb Portland is composed of two γ chains and two ζ chains5.
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References
Huehns, E. R., Dance, N., Beaven, G. H., Hecht, P., and Motulsky, A. G., Cold Spring Harb. Symp. quant. Biol., 29, 327–331 (1964).
Capp, G. L., Rigas, D. A., and Jones, R. T., Science, 157, 65–66 (1967).
Weatherall, D. J., Clegg, J. B., and Boon, W. H., Br. J. Haemat., 18, 357–367 (1970).
Todd, D., Lai, M. C. S., Beaven, G. H., and Huehns, E. R., Br. J. Haemat., 19, 27–31 (1970).
Capp, G. L., Rigas, D. A., and Jones, R. T., Nature, 228, 278–280 (1970).
Kamuzora, H., Jones, R. T., and Lehmann, H., FEBS Lett., 46, 195–199 (1974).
Perutz, M. F., and Mazarella, H., Nature, 199, 633–639 (1963).
Huehns, E. R., and Farooqui, A. M., Nature, 254, 335–337 (1975).
Lehmann, H., and Huntsman, R. G., Mans' Haemoglobins, second ed. (North Holland, Amsterdam, 1974).
Huisman, T. H. J., and Dozy, A. M., J. Chrom. 19, 160–169 (1965).
Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. molec. Biol. 19, 91–108 (1966).
Kuang-Tzu, D. L. N., and Deutsch, H. F., J. biol. Chem. 248, 1885–1893 (1973),
Szelenyi, J. F., and Hollan, S. R., Acta biochim. biophys. Acad. Sci. Hungary, 4, 47–55 (1969).
Gray, W. R., Methods in Enzymology, (edit. by Colowick, S. P., and Kaplan, N. O.), 11, 139–150 (Academic, New York and London, 1967).
Weiner, A. M., Platt, T., and Weber, K., J. biol. Chem. 247, 3242–3251 (1972).
Tuchinda, S., Nagai, K., and Lehmann, H., FEBS Lett., 49, 390–391 (1975).
Hecht, F., Motulsky, A. G., Lemire, R. F., and Shepard, T. D., Science, 152, 91–92 (1966).
Clegg, J. B., et al., Nature, 251, 245–247 (1974).
Perutz, M. F., Nature, 228, 726–739 (1970).
Perutz, M. F., and Ten Eyck, L. F., Cold Spring Harb. Symp. quant Biol., 36, 295–310 (1971).
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KAMUZORA, H., LEHMANN, H. Human embryonic haemoglobins including a comparison by homology of the human ζ and α chains. Nature 256, 511–513 (1975). https://doi.org/10.1038/256511a0
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DOI: https://doi.org/10.1038/256511a0
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