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Induced thermal resistance in HeLa cells

Naturevolume 256pages500502 (1975) | Download Citation

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Abstract

IN mammalian cells, hyperthermia causes temperature-dependent changes in cell growth parameters1, reduces DNA and protein synthesis rates2 and cell metabolism3, and leads to a loss of proliferative capacity4,5. Harris6 has shown that temperature-resistant pig kidney cells can be obtained after multiple exposures to very high thermal doses (colony-forming ability reduced to 10−5–10−6 of controls). The purpose of our experiments was to determine whether a single hyperthermic treatment (44 °C for 1 h) could induce a state of thermotolerance in cells, and if so, what was the mode of origin of the thermal resistant cells.

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References

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    Rao, P. N., and Engelbers, J., Science, 148, 1092–1904 (1965).

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    Palzer, R. J., and Heidelberger, C., Cancer Res., 33, 422–427 (1973).

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    Dickson, J. A., and Muckle, D. S., Cancer Res., 32, 1916–1923 (1972).

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    Westra, A., and Dewey, W. C., Int. J. Radiat. Biol., 19, 467–477 (1971).

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    Palzer, R. J., and Heidelberger, C., Cancer Res., 33, 415–421 (1973).

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    Harris, M., Expl Cell. Res., 46, 301–314 (1967).

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    Hahn, G., Cancer Res., 34, 3117–3123 (1974).

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Affiliations

  1. Division of Radiation Oncology, University of Arizona Medical School, Tucson, Arizona, 85724

    • EUGENE W. GERNER
    •  & MICHAEL J. SCHNEIDER

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https://doi.org/10.1038/256500a0

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