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Integration of viral genomes

Abstract

DNA transcripts of infectious RNA viruses were found to be integrated in the DNA of chronically-infected tissue cultures. DNA sequences homologous to RNA of measles virus were found in tissues affected with systemic lupus erythematosus. These data open up a new class of virus–cell interaction that may be a result of cooperation between infectious and oncogenic viruses.

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Zhdanov, V. Integration of viral genomes. Nature 256, 471–473 (1975). https://doi.org/10.1038/256471a0

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