Letter | Published:

Propagation of human wart virus in tissue culture

Naturevolume 256pages432434 (1975) | Download Citation

Subjects

Abstract

HUMAN wart (papilloma) virus (HWV) is an authentic human tumour virus. Based on morphology, it has been classified as a member of the papova group1 of animal tumour viruses. Using electron microscopy, HWV has been found to be associated with human skin warts2, laryngeal and venereal papillomas3,4 and epidermodysplasia verruciformis5. Moreover, experiments done with human volunteers at the beginning of this century6–8, showed that filtered extracts of warts, laryngeal and venereal papillomas can cause skin warts in man. Since these early experiments, there has been little increase in our knowledge of HWV as a causative agent of either benign tumours or those which can progress to malignancy5,9, mainly because of the lack of a system in which to propagate HWV in vitro10. This report describes the propagation of HWV in a tissue culture system.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Melnick, J. L., Science, 138, 1128–1130 (1962).

  2. 2

    Almeida, J. D., Howatson, A. F., and Williams, M. G., J. Invest. Dermat., 38, 337–345 (1962).

  3. 3

    Boyle, W. F., Riggs, J. L., Oshiro, L. S., and Lennette, E. H., Laryngoscope, 83, 1102–1108 (1973).

  4. 4

    Oirel, J. D., and Almeida, J. D., Br. J. vener. Dis., 46, 37–42 (1970).

  5. 5

    Ruiter, M., and Van Mullem, P. J., J. Invest. Dermat., 47, 247–250 (1966).

  6. 6

    Variot, G., J. clin. Therap. Infant., 2, 529–531 (1894).

  7. 7

    Ullman, E. V., Acta Otolaryng., 5, 317–334 (1923).

  8. 8

    Waelsch, L., Archs Dermat. Syph., 124, 625–646 (1917).

  9. 9

    Rosenbaum, H. D., Alavi, S. M., and Bryant, C. R., Radiology, 90, 4 (1968).

  10. 10

    Rowson, K. E. K., and Mahy, B. W., Bact. Rev., 11, 110–131 (1967).

  11. 11

    Murray, R. F., Hubbs, J., and Payne, B., Nature, 232, 50 (1971).

  12. 12

    Pass, F., and Marcus, D. M., J. Invest. Dermat., 60, 301–306 (1973).

  13. 13

    Pass, F., and Maizel, J. V., J. Invest. Dermat., 60, 307–311 (1973).

  14. 14

    Grawford, L. V., and Grawford, E. M., Virology, 21, 258–263 (1963).

  15. 15

    Black, P. H., Grawford, E. M., and Grawford, L. V., Virology, 24, 381–387 (1964).

  16. 16

    Ogilvie, M. M., J. Hyg., 68, 479–490 (1970).

  17. 17

    Almeida, F. D., Oriel, J. D., and Stannard, L. M., Microbios, 1, 225–232 (1969).

  18. 18

    Gardner, S. D., Coleman, D. V., Field, A. N., nad Hulme, B., Lancet, i, 1253–1257 (1971).

  19. 19

    Padgett, B. L., Zu Rhein, G., Walker, D. L., and Eckroade, R. J., Lancet, i, 1257–1260 (1971).

  20. 20

    Takemoto, K. K., et al., J. natn. Cancer Inst., 53, 1205–1207 (1974).

  21. 21

    Spencer, E. S., and Anderson, H. K., Br. med. J., 3, 251–254 (1970).

Download references

Author information

Affiliations

  1. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021

    • MAGDALENA EISINGER
    • , OLGA KUCAROVA
    • , NURUL H. SARKAR
    •  & ROBERT A. GOOD

Authors

  1. Search for MAGDALENA EISINGER in:

  2. Search for OLGA KUCAROVA in:

  3. Search for NURUL H. SARKAR in:

  4. Search for ROBERT A. GOOD in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/256432a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.